Zdhhc18 zinc finger, DHHC domain containing 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc18provided by MGI
Official Full Name: zinc finger, DHHC domain containing 18provided by MGI
Primary source: MGI:MGI:3527792
See related: Ensembl:ENSMUSG00000037553 AllianceGenome:MGI:3527792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DHHC-18
Summary: Enables palmitoyltransferase activity. Acts upstream of or within protein localization. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 53.1), thymus adult (RPKM 41.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133331969..133360801, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133604554..133633490, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Title: ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC18

Names: DHHC domain-containing cysteine-rich protein 18; zinc finger DHHC domain-containing protein 18

NP_001017968.2

EC 2.3.1.225

XP_006539081.1

EC 2.3.1.225

XP_006539083.1

EC 2.3.1.225

XP_006539084.1

EC 2.3.1.225

XP_006539085.1

EC 2.3.1.225

XP_011248601.1

EC 2.3.1.225

XP_017175794.1

EC 2.3.1.225

XP_036020116.1

EC 2.3.1.225

XP_036020117.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017968.2 → NP_001017968.2 palmitoyltransferase ZDHHC18

See identical proteins and their annotated locations for NP_001017968.2

Status: VALIDATED

Source sequence(s)

AL627228, AY668950, BX537327, CJ049628

Consensus CDS

CCDS38906.1

UniProtKB/Swiss-Prot

A2A9F0, Q5Y5T2

Related

ENSMUSP00000081260.5, ENSMUST00000084238.5

Conserved Domains (1) summary

pfam01529
Location:183 → 306

zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

133331969..133360801 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320305.3 → XP_017175794.1 palmitoyltransferase ZDHHC18 isoform X3

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase
XM_006539018.2 → XP_006539081.1 palmitoyltransferase ZDHHC18 isoform X1

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase
XM_011250299.3 → XP_011248601.1 palmitoyltransferase ZDHHC18 isoform X5

See identical proteins and their annotated locations for XP_011248601.1

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase
XM_036164223.1 → XP_036020116.1 palmitoyltransferase ZDHHC18 isoform X2

Conserved Domains (1) summary

pfam01529
Location:183 → 268

DHHC; DHHC palmitoyltransferase
XM_036164224.1 → XP_036020117.1 palmitoyltransferase ZDHHC18 isoform X6

Conserved Domains (1) summary

cl19890
Location:100 → 265

DHHC; DHHC palmitoyltransferase
XM_006539022.3 → XP_006539085.1 palmitoyltransferase ZDHHC18 isoform X5

See identical proteins and their annotated locations for XP_006539085.1

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase
XM_006539021.3 → XP_006539084.1 palmitoyltransferase ZDHHC18 isoform X4

See identical proteins and their annotated locations for XP_006539084.1

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase
XM_006539020.3 → XP_006539083.1 palmitoyltransferase ZDHHC18 isoform X4

See identical proteins and their annotated locations for XP_006539083.1

Conserved Domains (1) summary

pfam01529
Location:183 → 306

DHHC; DHHC palmitoyltransferase