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    Fam168b family with sequence similarity 168, member B [ Mus musculus (house mouse) ]

    Gene ID: 214469, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam168bprovided by MGI
    Official Full Name
    family with sequence similarity 168, member Bprovided by MGI
    Primary source
    MGI:MGI:2448487
    See related
    Ensembl:ENSMUSG00000037503 AllianceGenome:MGI:2448487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mani; mKIAA4042
    Summary
    Acts upstream of or within axonogenesis and gene expression. Is active in membrane. Is expressed in endolymphatic appendage and otocyst. Orthologous to human FAM168B (family with sequence similarity 168 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 73.1), thymus adult (RPKM 71.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam168b in Genome Data Viewer
    Location:
    1 B; 1 13.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34852307..34882094, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34813218..34843050, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene STARR-seq mESC enhancer starr_00584 Neighboring gene predicted gene, 32790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424 Neighboring gene uncharacterized protein C19orf29 homolog Neighboring gene STARR-seq mESC enhancer starr_00589 Neighboring gene STARR-seq mESC enhancer starr_00590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
    2. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
    3. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4042, MGC58017

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myelin-associated neurite-outgrowth inhibitor
    Names
    protein FAM168B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160235.2 → NP_001153707.1  myelin-associated neurite-outgrowth inhibitor isoform 1

      See identical proteins and their annotated locations for NP_001153707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site around the middle of the CDS compared to variant 4. It encodes isoform 1, which is shorter than isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS48236.1
      UniProtKB/TrEMBL
      G3UWF0
      Related
      ENSMUSP00000131720.2, ENSMUST00000167518.8
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 206
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. NM_001160236.2 → NP_001153708.1  myelin-associated neurite-outgrowth inhibitor isoform 2

      See identical proteins and their annotated locations for NP_001153708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' CDS compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS48235.1
      UniProtKB/TrEMBL
      E9Q917
      Related
      ENSMUSP00000128676.2, ENSMUST00000170092.8
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 201
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. NM_001403152.1 → NP_001390081.1  myelin-associated neurite-outgrowth inhibitor isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC107738

    4. NM_174997.3 → NP_778162.1  myelin-associated neurite-outgrowth inhibitor isoform 3

      See identical proteins and their annotated locations for NP_778162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' CDS and uses an alternate splice site near the central region of the CDS, compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC107738
      Consensus CDS
      CCDS14873.1
      UniProtKB/Swiss-Prot
      Q3UNC7, Q5DTR7, Q80XQ8
      Related
      ENSMUSP00000042212.6, ENSMUST00000047534.12
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 194
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34852307..34882094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XQ8.1 GenPept UniProtKB/Swiss-Prot:Q80XQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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