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    Eef2k eukaryotic elongation factor-2 kinase [ Mus musculus (house mouse) ]

    Gene ID: 13631, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eef2kprovided by MGI
    Official Full Name
    eukaryotic elongation factor-2 kinaseprovided by MGI
    Primary source
    MGI:MGI:1195261
    See related
    Ensembl:ENSMUSG00000035064 AllianceGenome:MGI:1195261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eEF-2K
    Summary
    Enables calmodulin binding activity and elongation factor-2 kinase activity. Involved in regulation of protein autophosphorylation. Predicted to be located in dendritic spine. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in liver; lung; nervous system; and olfactory epithelium. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 19.4), colon adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eef2k in Genome Data Viewer
    Location:
    7 F2; 7 64.95 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120442080..120506441)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120842642..120907219)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6592 Neighboring gene STARR-positive B cell enhancer ABC_E1360 Neighboring gene STARR-positive B cell enhancer ABC_E10469 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG) Neighboring gene predicted gene, 36449 Neighboring gene predicted gene 15774 Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. Zhang P, et al. Can J Cardiol, 2014 Dec. PMID 25475470, Free PMC Article
    2. Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. Gschwendt M, et al. FEBS Lett, 1994 Jan 24. PMID 8307162
    3. Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Khan AA, et al. Am J Pathol, 2010 Jul. PMID 20472894, Free PMC Article
    4. Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Gildish I, et al. Learn Mem, 2012 Feb 24. PMID 22366775, Free PMC Article
    5. Germline quality control: eEF2K stands guard to eliminate defective oocytes. Chu HP, et al. Dev Cell, 2014 Mar 10. PMID 24582807, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
      Title: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
    2. Control of CD4[+] T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
      Title: Control of CD4(+) T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
    3. Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24[Bst] Mouse.
      Title: Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse.
    4. eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
      Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
    5. miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
      Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
    6. [Effects of GSK3beta/eEF2K signaling pathway on pulmonary fibrosis in mice].
      Title: [Effects of GSK3β/eEF2K signaling pathway on pulmonary fibrosis in mice].
    7. Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
      Title: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
    8. Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
      Title: Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
    9. Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
      Title: Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
    10. Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
      Title: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables elongation factor-2 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables elongation factor-2 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables elongation factor-2 kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to anoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myosin II filament disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation at postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation at postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to prolactin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic elongation factor 2 kinase
    Names
    calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
    eEF-2 kinase
    eukaroytic elongation factor 2 kinase
    NP_001254639.1
    NP_001254640.1
    NP_001399257.1
    NP_001399258.1
    NP_001399259.1
    NP_001399260.1
    NP_001399261.1
    NP_001399262.1
    NP_001399263.1
    NP_031934.1
    XP_036008548.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267710.2 → NP_001254639.1  eukaryotic elongation factor 2 kinase isoform a

      See identical proteins and their annotated locations for NP_001254639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC122214, AC122248
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q7TPC7, Q8BNP6, Q8CEC8
      Related
      ENSMUSP00000102098.2, ENSMUST00000106489.9
      Conserved Domains (3) summary
      COG0790
      Location:492 → 688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502 → 535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102 → 317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    2. NM_001267711.2 → NP_001254640.1  eukaryotic elongation factor 2 kinase isoform a

      See identical proteins and their annotated locations for NP_001254640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC122214, AC122248
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q7TPC7, Q8BNP6, Q8CEC8
      Related
      ENSMUSP00000102097.2, ENSMUST00000106488.3
      Conserved Domains (3) summary
      COG0790
      Location:492 → 688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502 → 535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102 → 317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    3. NM_001412328.1 → NP_001399257.1  eukaryotic elongation factor 2 kinase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248
      UniProtKB/Swiss-Prot
      O08796

    4. NM_001412329.1 → NP_001399258.1  eukaryotic elongation factor 2 kinase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248
      UniProtKB/Swiss-Prot
      O08796

    5. NM_001412330.1 → NP_001399259.1  eukaryotic elongation factor 2 kinase isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248
      UniProtKB/Swiss-Prot
      O08796

    6. NM_001412331.1 → NP_001399260.1  eukaryotic elongation factor 2 kinase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248

    7. NM_001412332.1 → NP_001399261.1  eukaryotic elongation factor 2 kinase isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248

    8. NM_001412333.1 → NP_001399262.1  eukaryotic elongation factor 2 kinase isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248

    9. NM_001412334.1 → NP_001399263.1  eukaryotic elongation factor 2 kinase isoform d

      Status: VALIDATED

      Source sequence(s)
      AC122248

    10. NM_007908.5 → NP_031934.1  eukaryotic elongation factor 2 kinase isoform a

      See identical proteins and their annotated locations for NP_031934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC122214, AC122248
      Consensus CDS
      CCDS21796.1
      UniProtKB/Swiss-Prot
      O08796
      UniProtKB/TrEMBL
      Q7TPC7, Q8BNP6, Q8CEC8
      Related
      ENSMUSP00000046595.9, ENSMUST00000047875.16
      Conserved Domains (3) summary
      COG0790
      Location:492 → 688
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:502 → 535
      SLR; SLR repeat [structural motif]
      cd16967
      Location:102 → 317
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

    RNA

    1. NR_178189.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122214, AC122248

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120442080..120506441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152655.1 → XP_036008548.1  eukaryotic elongation factor 2 kinase isoform X4

      UniProtKB/TrEMBL
      Q8BNP6
      Conserved Domains (3) summary
      COG0790
      Location:351 → 547
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:361 → 394
      SLR; SLR repeat [structural motif]
      cd16967
      Location:1 → 176
      Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08796.1 GenPept UniProtKB/Swiss-Prot:O08796

    Gene LinkOut

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