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    Dlgap1 DLG associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 224997, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dlgap1provided by MGI
    Official Full Name
    DLG associated protein 1provided by MGI
    Primary source
    MGI:MGI:1346065
    See related
    Ensembl:ENSMUSG00000003279 AllianceGenome:MGI:1346065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gkap; Sapap1; mKIAA4162; 9630002F18; GKAP/SAPAP; GKPA/SAPAP; D17Bwg0511e; 4933422O14Rik
    Summary
    Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within chemical synaptic transmission. Located in postsynaptic density. Is expressed in cortical plate and hippocampus. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 40.8), cortex adult (RPKM 32.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dlgap1 in Genome Data Viewer
    Location:
    17 E1.3; 17 40.85 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (70276068..71128408)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69969073..70821413)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43132 Neighboring gene predicted gene, 36594 Neighboring gene programmed cell death 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43133 Neighboring gene stathmin 1, related sequence 2 Neighboring gene STARR-seq mESC enhancer starr_43136 Neighboring gene dephospho-CoA kinase domain containing pseudogene Neighboring gene predicted gene, 46581 Neighboring gene predicted gene, 36746 Neighboring gene STARR-seq mESC enhancer starr_43142 Neighboring gene STARR-seq mESC enhancer starr_43143 Neighboring gene STARR-seq mESC enhancer starr_43144 Neighboring gene STARR-positive B cell enhancer ABC_E9441 Neighboring gene STARR-seq mESC enhancer starr_43149 Neighboring gene STARR-seq mESC enhancer starr_43152 Neighboring gene STARR-seq mESC enhancer starr_43157 Neighboring gene predicted gene, 41609 Neighboring gene STARR-seq mESC enhancer starr_43159 Neighboring gene STARR-positive B cell enhancer ABC_E8692 Neighboring gene STARR-positive B cell enhancer ABC_E7553 Neighboring gene predicted gene, 41610 Neighboring gene TGFB-induced factor homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis. Zhang J, et al. Lipids Health Dis, 2020 Mar 13. PMID 32169116, Free PMC Article
    2. Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. Coba MP, et al. Sci Rep, 2018 Feb 2. PMID 29396406, Free PMC Article
    3. Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein. Ishioka K, et al. Retrovirology, 2006 Oct 17. PMID 17042961, Free PMC Article
    4. Synapse structure: glutamate receptors connected by the shanks. Ehlers MD. Curr Biol, 1999 Nov 18. PMID 10574750
    5. PSD93 regulates synaptic stability at neuronal cholinergic synapses. Parker MJ, et al. J Neurosci, 2004 Jan 14. PMID 14724236, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
      Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
    2. Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
      Title: Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
    3. These data suggest that Dlgap1 knockout leads to post-synaptic density disruption and reduced sociability, consistent with reports of DLGAP1 haploinsufficient variants in schizophrenia and autism spectrum disorder.
      Title: Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.
    4. GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
      Title: GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
    5. Expression of Dlgap1 in the mouse prefrontal cortex is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
      Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
    6. Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP.
      Title: Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.
    7. the loss of the SH3, protein 4.1 and/or GUK domains of Dlg1 disrupt epithelial polarity and perturb nephrogenesis either as a secondary consequence to a defect in ureteric branching morphogenesis and/or delay in mesenchyme-to- epithelial transition
      Title: Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney.
    8. results suggest that inactivation of Dlg1 augments HTLV-1 Tax-mediated transformation of the T-cell line (CTLL-2)
      Title: Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4162

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disks large-associated protein 1
    Names
    DAP-1 beta
    PSD-95/SAP90-binding protein 1
    SAP90/PSD-95 associated protein 1
    discs, large homolog-associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128180.1 → NP_001121652.1  disks large-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC079441, AC154769, AC163902
      Consensus CDS
      CCDS50172.1
      UniProtKB/TrEMBL
      E9QAR5, Q3TSN1
      Related
      ENSMUSP00000122337.2, ENSMUST00000148486.8
      Conserved Domains (1) summary
      pfam03359
      Location:350 → 682
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. NM_001128181.1 → NP_001121653.1  disks large-associated protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001121653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes alternate exons in the 5' and 3' ends of the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 4 which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC079441, AC163902
      Consensus CDS
      CCDS50173.1
      UniProtKB/TrEMBL
      A0A3B2W7Z1, Q3UVU8
      Related
      ENSMUSP00000094890.3, ENSMUST00000097288.4
      Conserved Domains (1) summary
      pfam03359
      Location:352 → 618
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. NM_001347411.1 → NP_001334340.1  disks large-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
      Consensus CDS
      CCDS84331.1
      UniProtKB/TrEMBL
      D3Z709
      Related
      ENSMUSP00000118497.2, ENSMUST00000135938.8

    4. NM_001347412.1 → NP_001334341.1  disks large-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
      Consensus CDS
      CCDS84332.1
      UniProtKB/TrEMBL
      D3Z709, Q3UHD8
      Related
      ENSMUSP00000116716.2, ENSMUST00000133983.8
      Conserved Domains (1) summary
      pfam03359
      Location:650 → 982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. NM_001347413.1 → NP_001334342.1  disks large-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154769, AC163902, AI837331
      Consensus CDS
      CCDS84333.1
      UniProtKB/TrEMBL
      D3Z508, Q3TSN1
      Related
      ENSMUSP00000117358.2, ENSMUST00000140728.8

    6. NM_001347414.1 → NP_001334343.1  disks large-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154769, AC163902, AI837331
      Consensus CDS
      CCDS84334.1
      UniProtKB/TrEMBL
      D3Z6F4, Q3TSN1
      Related
      ENSMUSP00000122370.2, ENSMUST00000133717.9

    7. NM_001360665.1 → NP_001347594.1  disks large-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AC168117
      Consensus CDS
      CCDS84332.1
      UniProtKB/TrEMBL
      D3Z709, Q3UHD8
      Related
      ENSMUSP00000052858.6, ENSMUST00000060072.12
      Conserved Domains (1) summary
      pfam03359
      Location:650 → 982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. NM_027712.3 → NP_081988.3  disks large-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154769, BC094369
      UniProtKB/TrEMBL
      D3Z709
      Related
      ENSMUSP00000116072.2, ENSMUST00000146730.9
      Conserved Domains (1) summary
      pfam03359
      Location:650 → 916
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. NM_177639.6 → NP_808307.2  disks large-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_808307.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079441, AC154769, AC163902
      Consensus CDS
      CCDS28953.1
      UniProtKB/Swiss-Prot
      Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
      UniProtKB/TrEMBL
      D3Z709
      Related
      ENSMUSP00000122896.2, ENSMUST00000155016.8
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      70276068..71128408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160564.1 → XP_036016457.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      D3Z709, Q3UHD8
      Conserved Domains (1) summary
      pfam03359
      Location:650 → 982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    2. XM_036160565.1 → XP_036016458.1  disks large-associated protein 1 isoform X7

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:622 → 954
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    3. XM_006524173.3 → XP_006524236.1  disks large-associated protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006524236.1

      UniProtKB/Swiss-Prot
      Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    4. XM_036160562.1 → XP_036016455.1  disks large-associated protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    5. XM_011246406.3 → XP_011244708.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244708.1

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:698 → 1030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    6. XM_011246407.3 → XP_011244709.1  disks large-associated protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011244709.1

      UniProtKB/Swiss-Prot
      Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    7. XM_006524169.3 → XP_006524232.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524232.1

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:698 → 1030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    8. XM_030249738.1 → XP_030105598.1  disks large-associated protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0, Q9D415
      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    9. XM_036160563.1 → XP_036016456.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      D3Z709, Q3UHD8
      Conserved Domains (1) summary
      pfam03359
      Location:650 → 982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    10. XM_006524168.3 → XP_006524231.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524231.1

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:698 → 1030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    11. XM_006524172.3 → XP_006524235.1  disks large-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:670 → 1002
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    12. XM_006524171.3 → XP_006524234.1  disks large-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:688 → 1020
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    13. XM_006524174.3 → XP_006524237.1  disks large-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      D3Z709
      Conserved Domains (1) summary
      pfam03359
      Location:660 → 992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    14. XM_006524177.5 → XP_006524240.3  disks large-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:431 → 763
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    15. XM_006524178.5 → XP_006524241.3  disks large-associated protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:393 → 725
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    16. XM_030249741.2 → XP_030105601.2  disks large-associated protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:365 → 697
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    17. XM_030249739.2 → XP_030105599.2  disks large-associated protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:383 → 715
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    18. XM_006524183.5 → XP_006524246.3  disks large-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A3B2WD59
      Related
      ENSMUSP00000156863.2, ENSMUST00000233283.2
      Conserved Domains (1) summary
      pfam03359
      Location:355 → 687
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    19. XM_017317449.2 → XP_017172938.1  disks large-associated protein 1 isoform X19

      UniProtKB/TrEMBL
      Q3TSN1
      Conserved Domains (1) summary
      pfam03359
      Location:332 → 664
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    20. XM_017317450.2 → XP_017172939.1  disks large-associated protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:322 → 654
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    21. XM_006524181.1 → XP_006524244.1  disks large-associated protein 1 isoform X14

      UniProtKB/TrEMBL
      Q3TSN1
      Conserved Domains (1) summary
      pfam03359
      Location:362 → 694
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    22. XM_006524185.1 → XP_006524248.1  disks large-associated protein 1 isoform X17

      UniProtKB/TrEMBL
      Q3TSN1
      Conserved Domains (1) summary
      pfam03359
      Location:352 → 684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    23. XM_036160566.1 → XP_036016459.1  disks large-associated protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:324 → 656
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    24. XM_006524184.4 → XP_006524247.1  disks large-associated protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:352 → 684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    25. XM_036160567.1 → XP_036016460.1  disks large-associated protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:324 → 656
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    26. XM_030249742.1 → XP_030105602.1  disks large-associated protein 1 isoform X18

      UniProtKB/TrEMBL
      Q3TSN1
      Conserved Domains (1) summary
      pfam03359
      Location:342 → 674
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    27. XM_006524179.5 → XP_006524242.1  disks large-associated protein 1 isoform X10

      UniProtKB/TrEMBL
      Q3TSN1
      Conserved Domains (1) summary
      pfam03359
      Location:390 → 722
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    28. XM_006524180.2 → XP_006524243.2  disks large-associated protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A3B2WD59
      Conserved Domains (1) summary
      pfam03359
      Location:343 → 675
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D415.3 GenPept UniProtKB/Swiss-Prot:Q9D415

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