Trim24 tripartite motif-containing 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim24provided by MGI
Official Full Name: tripartite motif-containing 24provided by MGI
Primary source: MGI:MGI:109275
See related: Ensembl:ENSMUSG00000029833 AllianceGenome:MGI:109275
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TIF1; Tif1a; TIF1alpha; TIF1-alpha; A130082H20Rik; D430004I05Rik
Summary: The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in testis adult (RPKM 15.5), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 17.07 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (37846816..37945380)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (37870811..37968445)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNbeta1 transcription during macrophage activation.
Title: Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNβ1 transcription during macrophage activation.
TRIM24 is an insulin-responsive regulator of P-bodies.
Title: TRIM24 is an insulin-responsive regulator of P-bodies.
Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway.
Title: Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway.
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Title: Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Title: TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.
Title: TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.
Loss of transcriptional intermediary factor 1 alpha (Trim24) inhibits signal transducer and activator of transcription 6 (Stat6) acetylation and thus promotes M2 polarization in macrophages, potentially compromising antitumor immune responses.
Title: Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2, and Nanog; Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
Title: Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins.
data identify a previously unappreciated Trim24-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 in TH2-mediated allergy and antihelminth immunity
Title: T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.
Trim24 repressed VL30-class endogenous retroviruses retrotransposons
Title: Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Braf (e-PCR), detects polymorphism
- UniSTS:141185

NoName (e-PCR)
- UniSTS:235413

RH132996 (e-PCR)
- UniSTS:216279

D6Jpk1 (e-PCR), detects polymorphism
- UniSTS:142580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	ISS Inferred from Sequence or Structural Similarity more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of vitamin D receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perichromatin fibrils	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription intermediary factor 1-alpha

Names: E3 ubiquitin-protein ligase Trim24; RING-type E3 ubiquitin transferase TIF1-alpha; transcriptional intermediary factor 1, alpha; tripartite motif-containing protein 24

NP_001258993.1

EC 2.3.2.27

NP_001259005.1

EC 2.3.2.27

NP_659542.3

EC 2.3.2.27

XP_006505958.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001272064.1 → NP_001258993.1 transcription intermediary factor 1-alpha isoform 2

See identical proteins and their annotated locations for NP_001258993.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC113501, S78219

Consensus CDS

CCDS71751.1

UniProtKB/TrEMBL

Q3V0H4

Related

ENSMUSP00000113063.2, ENSMUST00000120428.8

Conserved Domains (6) summary

cd05502
Location:867 → 974

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:266 → 392

BBC; B-Box C-terminal domain

smart00336
Location:158 → 194

BBOX; B-Box-type zinc finger

smart00184
Location:52 → 78

RING; Ring finger

cd00021
Location:221 → 259

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15624
Location:795 → 840

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
NM_001272076.1 → NP_001259005.1 transcription intermediary factor 1-alpha isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus that lacks the N-terminal RING domain, compared to isoform 1.

Source sequence(s)

AC113501, AK133144, S78219

Consensus CDS

CCDS71752.1

UniProtKB/TrEMBL

E9Q1U8, Q3V0H4

Related

ENSMUSP00000114001.2, ENSMUST00000120238.2

Conserved Domains (5) summary

cd05502
Location:831 → 938

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:196 → 322

BBC; B-Box C-terminal domain

smart00336
Location:88 → 124

BBOX; B-Box-type zinc finger

cd00021
Location:151 → 189

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15624
Location:759 → 804

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
NM_145076.4 → NP_659542.3 transcription intermediary factor 1-alpha isoform 1

See identical proteins and their annotated locations for NP_659542.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC113501, S78221

Consensus CDS

CCDS20008.1

UniProtKB/Swiss-Prot

Q64126, Q64127

UniProtKB/TrEMBL

Q3V0H4

Related

ENSMUSP00000031859.8, ENSMUST00000031859.14

Conserved Domains (6) summary

cd05502
Location:901 → 1008

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:266 → 392

BBC; B-Box C-terminal domain

smart00336
Location:158 → 194

BBOX; B-Box-type zinc finger

smart00184
Location:52 → 78

RING; Ring finger

cd00021
Location:221 → 259

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd15624
Location:829 → 874

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

37846816..37945380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505895.4 → XP_006505958.1 transcription intermediary factor 1-alpha isoform X1

UniProtKB/TrEMBL

Q3TLF2

Conserved Domains (4) summary

cd05502
Location:624 → 731

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:1 → 115

BBC; B-Box C-terminal domain

cd15624
Location:552 → 597

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

pfam09770
Location:152 → 288

PAT1; Topoisomerase II-associated protein PAT1