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    Tsn translin [ Mus musculus (house mouse) ]

    Gene ID: 22099, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tsnprovided by MGI
    Official Full Name
    translinprovided by MGI
    Primary source
    MGI:MGI:109263
    See related
    Ensembl:ENSMUSG00000026374 AllianceGenome:MGI:109263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3PO; TB-RBP; 2610034C24Rik
    Summary
    Enables mRNA binding activity. Predicted to be involved in siRNA processing. Located in cytoplasm and male germ cell nucleus. Orthologous to human TSN (translin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 26.5), CNS E14 (RPKM 24.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tsn in Genome Data Viewer
    Location:
    1 E2.3; 1 52.14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118226244..118239463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118298514..118311461, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene retinoblastoma binding protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01974 Neighboring gene predicted gene, 53580 Neighboring gene STARR-seq mESC enhancer starr_01975 Neighboring gene STARR-positive B cell enhancer ABC_E5790 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 Neighboring gene predicted gene 28867

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein. Muramatsu T, et al. Biochem Biophys Res Commun, 1998 Jun 9. PMID 9636644
    2. Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities. Wang J, et al. Biochemistry, 2004 Oct 26. PMID 15491149
    3. Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. Stein JM, et al. J Neurosci, 2006 Feb 22. PMID 16495445, Free PMC Article
    4. Contribution of Translin to hematopoietic regeneration after sublethal ionizing irradiation. Fukuda Y, et al. Biol Pharm Bull, 2008 Feb. PMID 18239274
    5. The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability. Yu Z, et al. J Androl, 2008 Sep-Oct. PMID 18567644

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation.
      Title: Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation.
    2. Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
      Title: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
    3. Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
      Title: Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
    4. Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.
      Title: Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.
    5. Primary cultures of Translin-null mammary epithelial cells showed augmented DNA synthesis in a ligand-independent and ligand-enhanced manner. Translin-null ovariectomized mice implanted with slow-release estrogen pellets showed enhanced length and ramification of the mammary glands.
      Title: Translin restricts the growth of pubertal mammary epithelial cells estrogen-independently in mice.
    6. Deletion of the TN/TX complex selectively increases aortic miR-181b and prevents increased vascular stiffness caused by ingestion of high-salt water.
      Title: Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness.
    7. Translin plays an intrinsic role in restricting mesenchymal cell proliferation and differentiation
      Title: Translin modulates mesenchymal cell proliferation and differentiation in mice.
    8. Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
      Title: Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
    9. These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.
      Title: Rescuing dicer defects via inhibition of an anti-dicing nuclease.
    10. These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms.
      Title: Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in siRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of endoribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translin
    Names
    component 3 of promoter of RISC
    testis/brain-RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011650.4 → NP_035780.1  translin

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding variant.
      Source sequence(s)
      AC121531, CX243508
      Consensus CDS
      CCDS35690.1
      UniProtKB/Swiss-Prot
      Q62348
      UniProtKB/TrEMBL
      Q545E6
      Related
      ENSMUSP00000027623.8, ENSMUST00000027623.9
      Conserved Domains (1) summary
      cd14819
      Location:10 → 216
      Translin; also known as TB-RBP (testis brain RNA-binding protein)

    RNA

    1. NR_153836.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks the translational start codon and a believable ORF, compared to variant 1.
      Source sequence(s)
      AC121531

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      118226244..118239463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252998.2 → XP_030108858.1  translin isoform X1

      Conserved Domains (1) summary
      cl00957
      Location:10 → 126
      Translin-like; Translin and translin-associated factor-X (TRAX)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62348.1 GenPept UniProtKB/Swiss-Prot:Q62348

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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