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    Zfx zinc finger protein X-linked [ Mus musculus (house mouse) ]

    Gene ID: 22764, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfxprovided by MGI
    Official Full Name
    zinc finger protein X-linkedprovided by MGI
    Primary source
    MGI:MGI:99211
    See related
    Ensembl:ENSMUSG00000079509 AllianceGenome:MGI:99211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfx5; Zfx6; Zfx5,6
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Acts upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; central nervous system; genitourinary system; ileum; and spleen. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.9), CNS E11.5 (RPKM 4.7) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zfx in Genome Data Viewer
    Location:
    X C3; X 41.48 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93118237..93194250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94074631..94150645, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15165 Neighboring gene STARR-seq mESC enhancer starr_47553 Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger X-chromosomal protein
    Names
    X-linked zinc finger protein
    zinc finger protein X-linked 5
    zinc finger protein X-linked 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044386.1NP_001037851.1  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_001037851.1

      Status: VALIDATED

      Source sequence(s)
      AL626786, BF022794
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000085423.6, ENSMUST00000088102.12
      Conserved Domains (6) summary
      COG5048
      Location:537674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    2. NM_001358354.2NP_001345283.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
      Conserved Domains (5) summary
      COG5048
      Location:487624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:663685
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71354
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:677701
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001358355.2NP_001345284.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
      Conserved Domains (5) summary
      COG5048
      Location:487624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:663685
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71354
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:677701
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001358356.2NP_001345285.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Conserved Domains (6) summary
      COG5048
      Location:537674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein
    5. NM_001358357.1NP_001345286.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786, BC028506
      Consensus CDS
      CCDS90734.1
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
      Related
      ENSMUSP00000109558.2, ENSMUST00000113925.8
      Conserved Domains (1) summary
      pfam04704
      Location:71210
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    6. NM_001426089.1NP_001413018.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    7. NM_001426091.1NP_001413020.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
    8. NM_001426092.1NP_001413021.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    9. NM_001426093.1NP_001413022.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    10. NM_001426094.1NP_001413023.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    11. NM_001426095.1NP_001413024.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000109559.2, ENSMUST00000113926.8
    12. NM_001426096.1NP_001413025.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    13. NM_001426097.1NP_001413026.1  zinc finger X-chromosomal protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
    14. NM_001426098.1NP_001413027.1  zinc finger X-chromosomal protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
    15. NM_001426099.1NP_001413028.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
    16. NM_001426100.1NP_001413029.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
    17. NM_001426101.1NP_001413030.1  zinc finger X-chromosomal protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
      UniProtKB/TrEMBL
      B7ZN32
    18. NM_001426102.1NP_001413031.1  zinc finger X-chromosomal protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P23607
    19. NM_001426103.1NP_001413032.1  zinc finger X-chromosomal protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
    20. NM_001426104.1NP_001413033.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    21. NM_001426105.1NP_001413034.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    22. NM_001426106.1NP_001413035.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    23. NM_001426107.1NP_001413036.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    24. NM_001426108.1NP_001413037.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    25. NM_001426109.1NP_001413038.1  zinc finger X-chromosomal protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL626786
      UniProtKB/TrEMBL
      B1ASD2, Q8R2L1
    26. NM_011768.2NP_035898.2  zinc finger X-chromosomal protein isoform 1

      See identical proteins and their annotated locations for NP_035898.2

      Status: VALIDATED

      Source sequence(s)
      AL626786, BF022794
      Consensus CDS
      CCDS30276.1
      UniProtKB/Swiss-Prot
      P17011, P17012, P23607
      UniProtKB/TrEMBL
      B1ASD1
      Related
      ENSMUSP00000109560.2, ENSMUST00000113927.8
      Conserved Domains (6) summary
      COG5048
      Location:537674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:484504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713735
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:71404
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:727751
      zf-H2C2_2; Zinc-finger double domain
      cl19880
      Location:371451
      ROS_MUCR; ROS/MUCR transcriptional regulator protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93118237..93194250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527967.4XP_006528030.1  zinc finger X-chromosomal protein isoform X3

      UniProtKB/Swiss-Prot
      P23607
      Conserved Domains (5) summary
      COG5048
      Location:520644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467487
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:696718
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:104387
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:539563
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006527965.4XP_006528028.1  zinc finger X-chromosomal protein isoform X1

      UniProtKB/Swiss-Prot
      P23607
      Conserved Domains (4) summary
      COG5048
      Location:570832
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:452474
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:104437
      Zfx_Zfy_act; Zfx / Zfy transcription activation region