Fkbp10 FK506 binding protein 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp10provided by MGI
Official Full Name: FK506 binding protein 10provided by MGI
Primary source: MGI:MGI:104769
See related: Ensembl:ENSMUSG00000001555 AllianceGenome:MGI:104769
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fkbp6; FKBP65; Fkbprp; FKBP-10; FKBP-65; Fkbp-rs1; Fkbp1-rs
Summary: Enables FK506 binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within several processes, including aorta morphogenesis; extracellular matrix organization; and peptidyl-lysine hydroxylation. Located in endoplasmic reticulum; membrane; and mitochondrial intermembrane space. Is expressed in several structures, including brain vascular element; connective tissue; heart; metanephros; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 89.8), ovary adult (RPKM 79.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100306520..100315666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100415694..100424840)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta.
Title: Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta.
FKBP65 regulates LH2-mediated collagen cross-linking.
Title: FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
the altered collagen crosslinking through Fkbp10 ablation in osteoblasts primarily leads to a qualitative defect in the skeleton.
Title: Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone.
FKBP10 plays a crucial role in hypertrophic scar formation and maybe a therapeutic target for hypertrophic scars.
Title: Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition.
Data suggest a requirement for FKBP65 function during embryonic connective tissue development in mice; its expression is restricted postnatally in bone, ligaments and tendons.
Title: Connective tissue alterations in Fkbp10-/- mice.
FKBP65 may act as an elastin chaperone in vivo by controlling both the coacervation and the maturation stages of its selfassembly into fibrils.
Title: Effect of FKBP65, a putative elastin chaperone, on the coacervation of tropoelastin in vitro.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FK506 binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-lysine hydroxylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-proline modification	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP10

Names: 65 kDa FK506-binding protein; 65 kDa FKBP; FK506 binding protein 6 (65 kDa); PPIase FKBP10; immunophilin FKBP65; rotamase

NP_001156953.1

EC 5.2.1.8

NP_034351.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163481.1 → NP_001156953.1 peptidyl-prolyl cis-trans isomerase FKBP10 isoform 2 precursor

See identical proteins and their annotated locations for NP_001156953.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2) compared to isoform 1.

Source sequence(s)

AI846779, AL590968

UniProtKB/TrEMBL

A2A4H9, Q3UNJ3

Conserved Domains (3) summary

cd00051
Location:504 → 565

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00254
Location:54 → 146

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam13499
Location:503 → 566

EF-hand_7; EF-hand domain pair
NM_010221.2 → NP_034351.2 peptidyl-prolyl cis-trans isomerase FKBP10 isoform 1 precursor

See identical proteins and their annotated locations for NP_034351.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AI846779, AK019446, AL590968, BY311176

Consensus CDS

CCDS25422.1

UniProtKB/Swiss-Prot

A2A4I0, Q61576, Q8VHI1

UniProtKB/TrEMBL

A2A4H9

Related

ENSMUSP00000001595.4, ENSMUST00000001595.10

Conserved Domains (3) summary

cd00051
Location:505 → 566

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00254
Location:54 → 146

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

pfam13499
Location:504 → 567

EF-hand_7; EF-hand domain pair