U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptdss1 phosphatidylserine synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19210, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ptdss1provided by MGI
    Official Full Name
    phosphatidylserine synthase 1provided by MGI
    Primary source
    MGI:MGI:1276575
    See related
    Ensembl:ENSMUSG00000021518 AllianceGenome:MGI:1276575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSS-1; mKIAA0024
    Summary
    Enables L-serine-phosphatidylcholine phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to be involved in phosphatidylserine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 34.4), testis adult (RPKM 17.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptdss1 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67080894..67146465)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66932830..66998401)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67006259-67006368 Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene RNA guanine-7 methyltransferase activating subunit like Neighboring gene mitochondrial transcription termination factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10799 Neighboring gene STARR-seq mESC enhancer starr_34889 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085 Neighboring gene STARR-positive B cell enhancer ABC_E9879 Neighboring gene uncharacterized LOC118568057 Neighboring gene zinc finger protein 708 Neighboring gene tubulin, alpha 1B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    phosphatidylserine synthase 1
    Names
    PtdSer Synthase-1
    ptdSer synthase 1
    serine-exchange enzyme I
    NP_032985.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008959.3NP_032985.2  phosphatidylserine synthase 1

      See identical proteins and their annotated locations for NP_032985.2

      Status: VALIDATED

      Source sequence(s)
      AK054101, AK085857
      Consensus CDS
      CCDS26612.1
      UniProtKB/Swiss-Prot
      O55024, Q3UV14, Q8C2S8, Q99LH2
      UniProtKB/TrEMBL
      Q6A0E5
      Related
      ENSMUSP00000021990.4, ENSMUST00000021990.4
      Conserved Domains (1) summary
      pfam03034
      Location:96372
      PSS; Phosphatidyl serine synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67080894..67146465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)