Fgf22 fibroblast growth factor 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf22provided by MGI
Official Full Name: fibroblast growth factor 22provided by MGI
Primary source: MGI:MGI:1914362
See related: Ensembl:ENSMUSG00000020327 AllianceGenome:MGI:1914362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf5d; FGF-22; 2210414E06Rik
Summary: Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in regulation of synapse maturation and trans-synaptic signaling. Located in Golgi apparatus; cell surface; and nucleolus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Is extrinsic component of postsynaptic density membrane. Is expressed in brain; early conceptus; gonad; spinal cord; and tongue. Orthologous to human FGF22 (fibroblast growth factor 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 1.6), cortex adult (RPKM 1.1) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79590887..79593629)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79755051..79757795)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1.
Title: Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1.
Neuronal fibroblast growth factor 22 signaling during development, but not in adults, is involved in anhedonia.
Title: Neuronal fibroblast growth factor 22 signaling during development, but not in adults, is involved in anhedonia.
Here the authors show that fibroblast growth factor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
Title: Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain.
FGF22 restores hearing loss after gentamycin treatment by maintaining ribbon synapse number, likely via inhibition of MEF2D.
Title: FGF22 protects hearing function from gentamycin ototoxicity by maintaining ribbon synapse number.
In FGF22 knock-out mice, presynaptically, the number of synaptic vesicles is reduced, along with bouton volume and reduced number of vesicles in axonal regions.
Title: Presynaptic size of associational/commissural CA3 synapses is controlled by fibroblast growth factor 22 in adult mice.
we examine how the two presynaptic organizers FGF22 and FGF7 are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules.
Title: Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.
FGF22 is a synaptogenic mediator in the adult nervous system and a crucial regulator of synapse formation and maturation during post-injury remodeling in the spinal cord.
Title: FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis
Title: Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
Title: Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Fgf22 has a potential role in cutaneous development and repair.
Title: Fibroblast growth factor 22 and its potential role during skin development and repair.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf22 (e-PCR), detects polymorphism
- UniSTS:507924

Fgf22 (e-PCR), detects polymorphism
- UniSTS:516630

NoName (e-PCR)
- UniSTS:491450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 22

Names: fibroblast growth factor 5d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368662.2 → NP_001355591.1 fibroblast growth factor 22 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC151828

Consensus CDS

CCDS88050.1

UniProtKB/TrEMBL

Q0VER9

Related

ENSMUSP00000151917.2, ENSMUST00000219981.2

Conserved Domains (1) summary

cl00060
Location:34 → 97

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
NM_001429407.1 → NP_001416336.1 fibroblast growth factor 22 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AC151828
NM_023304.3 → NP_075793.1 fibroblast growth factor 22 isoform 1 precursor

See identical proteins and their annotated locations for NP_075793.1

Status: VALIDATED

Source sequence(s)

AC151828

Consensus CDS

CCDS23988.1

UniProtKB/Swiss-Prot

Q9ESS2

UniProtKB/TrEMBL

A0A7U3JW52

Related

ENSMUSP00000151743.2, ENSMUST00000219228.2

Conserved Domains (1) summary

pfam00167
Location:32 → 156

FGF; Fibroblast growth factor

RNA

NR_190732.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC151828
NR_190733.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC151828

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79590887..79593629

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245228.2 → XP_030101088.1 fibroblast growth factor 22 isoform X1

Related

ENSMUSP00000020577.4, ENSMUST00000020577.4

Conserved Domains (1) summary

cl00060
Location:34 → 97

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...