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    Ubl7 ubiquitin-like 7 (bone marrow stromal cell-derived) [ Mus musculus (house mouse) ]

    Gene ID: 69459, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ubl7provided by MGI
    Official Full Name
    ubiquitin-like 7 (bone marrow stromal cell-derived)provided by MGI
    Primary source
    MGI:MGI:1916709
    See related
    Ensembl:ENSMUSG00000055720 AllianceGenome:MGI:1916709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2300004C15Rik
    Summary
    Predicted to enable molecular adaptor activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human UBL7 (ubiquitin like 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 213.4), adrenal adult (RPKM 70.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubl7 in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57818280..57837624)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57910978..57929970)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24248 Neighboring gene STARR-seq mESC enhancer starr_24249 Neighboring gene predicted gene 7547 Neighboring gene meiotic nuclear divisions 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_24251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57758633-57758820 Neighboring gene sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57804760-57804959 Neighboring gene STARR-positive B cell enhancer ABC_E8291 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57816329-57816438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57819923-57820197 Neighboring gene STARR-seq mESC enhancer starr_24252 Neighboring gene STARR-positive B cell enhancer ABC_E2890 Neighboring gene STARR-seq mESC enhancer starr_24253 Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic Dissection of a QTL Affecting Bone Geometry. Sabik OL, et al. G3 (Bethesda), 2017 Mar 10. PMID 28082324, Free PMC Article
    2. UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS. Jiang W, et al. Cell Rep, 2023 Mar 28. PMID 36943869
    3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122873.2 → NP_001116345.1  ubiquitin-like protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001116345.1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      Consensus CDS
      CCDS23234.1
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5
      Related
      ENSMUSP00000126019.2, ENSMUST00000163329.2
      Conserved Domains (2) summary
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins
      cd01815
      Location:7 → 98
      Ubl_UBL7; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    2. NM_001413501.1 → NP_001400430.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5
      Related
      ENSMUSP00000149748.2, ENSMUST00000216841.2

    3. NM_001413502.1 → NP_001400431.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    4. NM_001413503.1 → NP_001400432.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    5. NM_001413504.1 → NP_001400433.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    6. NM_001413505.1 → NP_001400434.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    7. NM_001413506.1 → NP_001400435.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    8. NM_001413507.1 → NP_001400436.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    9. NM_001413508.1 → NP_001400437.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    10. NM_001413509.1 → NP_001400438.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    11. NM_001413510.1 → NP_001400439.1  ubiquitin-like protein 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5

    12. NM_001413511.1 → NP_001400440.1  ubiquitin-like protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122534

    13. NM_001413512.1 → NP_001400441.1  ubiquitin-like protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122534

    14. NM_001413513.1 → NP_001400442.1  ubiquitin-like protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122534

    15. NM_001413514.1 → NP_001400443.1  ubiquitin-like protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246

    16. NM_001413515.1 → NP_001400444.1  ubiquitin-like protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246

    17. NM_001413516.1 → NP_001400445.1  ubiquitin-like protein 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246

    18. NM_001413517.1 → NP_001400446.1  ubiquitin-like protein 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246

    19. NM_001413518.1 → NP_001400447.1  ubiquitin-like protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246

    20. NM_027086.4 → NP_081362.2  ubiquitin-like protein 7 isoform 1

      See identical proteins and their annotated locations for NP_081362.2

      Status: VALIDATED

      Source sequence(s)
      AC122534, AC165246
      Consensus CDS
      CCDS23234.1
      UniProtKB/Swiss-Prot
      E9Q1S0, Q91W67, Q9D7P5
      Related
      ENSMUSP00000150925.2, ENSMUST00000216925.2
      Conserved Domains (2) summary
      cd14326
      Location:346 → 375
      UBA_UBL7; UBA domain found in ubiquitin-like protein 7 (UBL7) and similar proteins
      cd01815
      Location:7 → 98
      Ubl_UBL7; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 7 (UBL7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57818280..57837624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W67.2 GenPept UniProtKB/Swiss-Prot:Q91W67

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