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    Chpf chondroitin polymerizing factor [ Mus musculus (house mouse) ]

    Gene ID: 74241, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chpfprovided by MGI
    Official Full Name
    chondroitin polymerizing factorprovided by MGI
    Primary source
    MGI:MGI:106576
    See related
    Ensembl:ENSMUSG00000032997 AllianceGenome:MGI:106576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Bwg1363e; 1700028N03Rik
    Summary
    Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Acts upstream of or within chondroitin sulfate biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHPF (chondroitin polymerizing factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 121.4), adrenal adult (RPKM 100.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chpf in Genome Data Viewer
    Location:
    1 C4; 1 39.14 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75451213..75456115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75474569..75479471, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase A Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene predicted gene, 53564 Neighboring gene acid-sensing ion channel family member 4 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene transmembrane protein 198 Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function. Ogawa H, et al. J Biol Chem, 2010 Oct 29. PMID 20729547, Free PMC Article
    2. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. Izumikawa T, et al. Biochem J, 2007 May 1. PMID 17253960, Free PMC Article
    3. Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons. Dorval V, et al. PLoS One, 2012. PMID 22952873, Free PMC Article
    4. MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer. Yun ZY, et al. Kaohsiung J Med Sci, 2024 Mar. PMID 38190270
    5. Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. Kuroda Y, et al. Hum Mol Genet, 2012 Mar 1. PMID 22082830

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer.
      Title: MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer.
    2. CSS2 mainly participated in the extension of chondroitin sulfate
      Title: Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.
    3. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function
      Title: Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate synthase 2
    Names
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
    N-acetylgalactosaminyltransferase 2
    chondroitin glucuronyltransferase 2
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
    NP_001001565.1
    NP_001001566.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001565.2 → NP_001001565.1  chondroitin sulfate synthase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the coding region and uses a downstream AUG compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC115011, BB651806, BC060598, BC071273
      Consensus CDS
      CCDS15075.1
      UniProtKB/Swiss-Prot
      Q6IQX7
      Related
      ENSMUSP00000092412.3, ENSMUST00000094818.4
      Conserved Domains (2) summary
      pfam05679
      Location:100 → 599
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:32 → 121
      Galactosyl_T; Galactosyltransferase

    2. NM_001001566.3 → NP_001001566.1  chondroitin sulfate synthase 2 isoform a

      See identical proteins and their annotated locations for NP_001001566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC115011, BC071273
      Consensus CDS
      CCDS15074.1
      UniProtKB/Swiss-Prot
      E9PUB9, Q6IQX7
      Related
      ENSMUSP00000078199.8, ENSMUST00000079205.14
      Conserved Domains (2) summary
      pfam05679
      Location:262 → 761
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:194 → 283
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75451213..75456115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IQX7.1 GenPept UniProtKB/Swiss-Prot:Q6IQX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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