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    Negr1 neuronal growth regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 320840, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Negr1provided by MGI
    Official Full Name
    neuronal growth regulator 1provided by MGI
    Primary source
    MGI:MGI:2444846
    See related
    Ensembl:ENSMUSG00000040037 AllianceGenome:MGI:2444846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntra; KILON; 5330422G01Rik
    Summary
    Predicted to enable transmembrane transporter binding activity. Acts upstream of or within several processes, including cholesterol homeostasis; lipid droplet formation; and nervous system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human NEGR1 (neuronal growth regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 8.0), frontal lobe adult (RPKM 7.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Negr1 in Genome Data Viewer
    Location:
    3 H4; 3 80.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (156266082..157022101)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (156561790..157316464)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene geminin pseudogene Neighboring gene STARR-seq mESC enhancer starr_09364 Neighboring gene predicted gene, 33311 Neighboring gene RIKEN cDNA 4930570G19 gene Neighboring gene predicted gene 42946 Neighboring gene STARR-seq mESC enhancer starr_09366 Neighboring gene STARR-seq mESC enhancer starr_09367 Neighboring gene STARR-seq mESC enhancer starr_09368 Neighboring gene predicted gene 43526 Neighboring gene predicted gene, 24373 Neighboring gene STARR-seq mESC enhancer starr_09369 Neighboring gene predicted gene, 23725 Neighboring gene predicted gene, 22458 Neighboring gene predicted gene, 23379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands. Lee J, et al. iScience, 2023 May 19. PMID 37216094, Free PMC Article
    2. Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Schäfer M, et al. Mol Cell Neurosci, 2005 Aug. PMID 15946856
    3. A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization. Pischedda F, et al. Mol Cell Proteomics, 2014 Mar. PMID 24382801, Free PMC Article
    4. Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene. Singh K, et al. Front Mol Neurosci, 2018. PMID 29479305, Free PMC Article
    5. Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass. Joo Y, et al. Int J Obes (Lond), 2019 Sep. PMID 31086253

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36.
      Title: Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36.
    2. Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders.
      Title: Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders.
    3. Studied role of Neuronal growth regulator 1 (Negr1) in adiposity and muscle mass using knockout model.
      Title: Neuronal growth regulator 1-deficient mice show increased adiposity and decreased muscle mass.
    4. The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively.
      Title: A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of neuronal growth regulator 1 (NEGR1) adhesion protein.
    5. Negr1 controls the development of neurite arborization in vitro and in vivo.
      Title: A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization.
    6. a role of NEGR1 in the control of body weight and food intake
      Title: Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
    7. These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation.
      Title: Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA3001

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal growth regulator 1
    Names
    kindred of IgLON
    neurotractin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039094.3 → NP_001034183.1  neuronal growth regulator 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001034183.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK147253, CA884108
      Consensus CDS
      CCDS17930.1
      UniProtKB/Swiss-Prot
      Q3UHQ8, Q80T70, Q80Z24
      Related
      ENSMUSP00000073664.5, ENSMUST00000074015.11
      Conserved Domains (4) summary
      cd00096
      Location:237 → 303
      Ig; Immunoglobulin domain
      smart00408
      Location:146 → 204
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:225 → 306
      IG_like; Immunoglobulin like
      cl11960
      Location:38 → 129
      Ig; Immunoglobulin domain

    2. NM_177274.4 → NP_796248.1  neuronal growth regulator 1 isoform b precursor

      See identical proteins and their annotated locations for NP_796248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon which results in a frameshift compared to variant 1. The encoded protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK035218, AK147253
      Consensus CDS
      CCDS17931.1
      UniProtKB/TrEMBL
      A0A4W9
      Related
      ENSMUSP00000041132.6, ENSMUST00000041425.12
      Conserved Domains (4) summary
      cd00096
      Location:237 → 303
      Ig; Immunoglobulin domain
      smart00408
      Location:146 → 204
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:225 → 306
      IG_like; Immunoglobulin like
      cl11960
      Location:38 → 129
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      156266082..157022101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163133.1 → XP_036019026.1  neuronal growth regulator 1 isoform X1

      Conserved Domains (4) summary
      smart00408
      Location:146 → 204
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:41 → 129
      IG_like; Immunoglobulin like
      pfam13927
      Location:219 → 295
      Ig_3; Immunoglobulin domain
      cd00096
      Location:219 → 225
      Ig; putative Ig strand A [structural motif]

    2. XM_006501578.4 → XP_006501641.1  neuronal growth regulator 1 isoform X3

      Conserved Domains (3) summary
      smart00408
      Location:146 → 204
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:41 → 129
      IG_like; Immunoglobulin like
      pfam13927
      Location:219 → 295
      Ig_3; Immunoglobulin domain

    3. XM_006501577.3 → XP_006501640.1  neuronal growth regulator 1 isoform X2

      See identical proteins and their annotated locations for XP_006501640.1

      UniProtKB/TrEMBL
      D3Z4T6
      Related
      ENSMUSP00000101680.2, ENSMUST00000106065.2
      Conserved Domains (3) summary
      smart00408
      Location:146 → 204
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:41 → 129
      IG_like; Immunoglobulin like
      pfam13927
      Location:219 → 295
      Ig_3; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Z24.1 GenPept UniProtKB/Swiss-Prot:Q80Z24

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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