Kif18a kinesin family member 18A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif18aprovided by MGI
Official Full Name: kinesin family member 18Aprovided by MGI
Primary source: MGI:MGI:2446977
See related: Ensembl:ENSMUSG00000027115 AllianceGenome:MGI:2446977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gcd2; B130001M12Rik
Summary: Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E14 (RPKM 8.8), CNS E11.5 (RPKM 7.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E3; 2 56.55 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (109111165..109172094)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (109280738..109341749)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
Title: Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates.
Title: Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
Kif18a is specifically required for mitotic progression during germ line development.
Title: Kif18a is specifically required for mitotic progression during germ line development.
In conclusion, Kif18a is critical for colorectal carcinogenesis in the setting of inflammation by mechanisms of increased PI3K-AKT signaling.
Title: Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (other) (1) 1 citation
Endonuclease-mediated (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU024633 (e-PCR)
- UniSTS:164170

RH132762 (e-PCR)
- UniSTS:216045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
enables tubulin-dependent ATPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle astral microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF18A

Names: N-8 kinesin; kinesin superfamily protein 18A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418960.1 → NP_001405889.1 kinesin-like protein KIF18A isoform 2

Status: VALIDATED

Source sequence(s)

AL691430
NM_001418961.1 → NP_001405890.1 kinesin-like protein KIF18A isoform 3

Status: VALIDATED

Source sequence(s)

AL691430

UniProtKB/TrEMBL

Q8BZ45

Related

ENSMUST00000144924.8
NM_001418962.1 → NP_001405891.1 kinesin-like protein KIF18A isoform 4

Status: VALIDATED

Source sequence(s)

AL691430

UniProtKB/TrEMBL

Q8BY99

Related

ENSMUST00000151395.8
NM_001418963.1 → NP_001405892.1 kinesin-like protein KIF18A isoform 5

Status: VALIDATED

Source sequence(s)

AL691430
NM_139303.2 → NP_647464.1 kinesin-like protein KIF18A isoform 1

See identical proteins and their annotated locations for NP_647464.1

Status: VALIDATED

Source sequence(s)

AL691430

Consensus CDS

CCDS16507.1

UniProtKB/Swiss-Prot

Q3TP77, Q8BLL1, Q91WD7

Related

ENSMUSP00000028527.8, ENSMUST00000028527.8

Conserved Domains (2) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

pfam00225
Location:17 → 355

Kinesin; Kinesin motor domain