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    Ttc5 tetratricopeptide repeat domain 5 [ Mus musculus (house mouse) ]

    Gene ID: 219022, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttc5provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 5provided by MGI
    Primary source
    MGI:MGI:2683584
    See related
    Ensembl:ENSMUSG00000006288 AllianceGenome:MGI:2683584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA binding activity and chromatin binding activity. Involved in DNA damage response and cellular response to starvation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in several cellular components, including cytoplasmic vesicle; cytosol; and mitochondrion. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.7), CNS E11.5 (RPKM 17.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc5 in Genome Data Viewer
    Location:
    14 C1; 14 26.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51002866..51022977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50765409..50785520, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24316 Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene cyclin B1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E753 Neighboring gene ribonuclease P RNA component H1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury. Pressly JD, et al. Sci Rep, 2017 Mar 3. PMID 28256593, Free PMC Article
    2. A new effector pathway links ATM kinase with the DNA damage response. Demonacos C, et al. Nat Cell Biol, 2004 Oct. PMID 15448695
    3. Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase. Maniam S, et al. Cell Death Differ, 2015 Jan. PMID 25168243, Free PMC Article
    4. A transcription cofactor required for the heat-shock response. Xu D, et al. EMBO Rep, 2008 Jul. PMID 18451878, Free PMC Article
    5. LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. Hu X, et al. J Cell Biol, 2019 Jan 7. PMID 30420355, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38092, 5930437N14

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 5
    Names
    TPR repeat protein 5
    protein Strap
    stress-responsive activator of p300

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080949.2 → NP_001074418.1  tetratricopeptide repeat protein 5 isoform a

      See identical proteins and their annotated locations for NP_001074418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC027184, AC140280, AK044781, AK133953, AK161279, BY278375
      Consensus CDS
      CCDS36905.1
      UniProtKB/Swiss-Prot
      Q3TTN5, Q3TZL6, Q99LG4
      UniProtKB/TrEMBL
      Q8C8M9
      Related
      ENSMUSP00000006451.7, ENSMUST00000006451.8
      Conserved Domains (3) summary
      sd00006
      Location:68 → 97
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:67 → 130
      TPR_11; TPR repeat
      pfam16669
      Location:318 → 430
      TTC5_OB; Tetratricopeptide repeat protein 5 OB fold domain

    2. NM_001360545.1 → NP_001347474.1  tetratricopeptide repeat protein 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC027184, AK044781, AK133953, AK161279, BY278375

    3. NM_177625.4 → NP_808293.1  tetratricopeptide repeat protein 5 isoform b

      See identical proteins and their annotated locations for NP_808293.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC027184, AK081214, AW046075, BY278375
      Consensus CDS
      CCDS88650.1
      UniProtKB/TrEMBL
      A0A2I3BRU0, Q8BNN3
      Related
      ENSMUSP00000154412.2, ENSMUST00000226768.2
      Conserved Domains (2) summary
      sd00006
      Location:68 → 97
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:67 → 130
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51002866..51022977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LG4.2 GenPept UniProtKB/Swiss-Prot:Q99LG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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