Flvcr2 FLVCR choline and putative heme transporter 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flvcr2provided by RGD
Official Full Name: FLVCR choline and putative heme transporter 2provided by RGD
Primary source: RGD:735098
See related: EnsemblRapid:ENSRNOG00000008754 AllianceGenome:RGD:735098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heme binding activity; heme transmembrane transporter activity; and organic cation transmembrane transporter activity. Predicted to be involved in choline transport; heme export; and transport across blood-brain barrier. Predicted to act upstream of or within several processes, including brain development; endothelial tip cell fate specification; and in utero embryonic development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 155.1), Adrenal (RPKM 142.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (111139352..111203345)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (105408355..105472355)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109617348..109681495)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables choline binding	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables choline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables choline transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanolamine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ethanolamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in choline transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISO Inferred from Sequence Orthology more info
involved_in choline transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endothelial tip cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in ethanolamine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in heme export	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: choline/ethanolamine transporter FLVCR2

Names: CCT; FLVCR heme transporter 2; calcium-chelate transporter; feline leukemia virus subgroup C cellular receptor family, member 2; feline leukemia virus subgroup C receptor-related protein 2; heme transporter FLVCR2; transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199109.3 → NP_954540.3 choline/ethanolamine transporter FLVCR2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P60815

UniProtKB/TrEMBL

A6JE38, F1LSF8, Q3T1I6

Related

ENSRNOP00000011599.7, ENSRNOT00000011599.8

Conserved Domains (1) summary

cl28910
Location:100 → 505

MFS; Major Facilitator Superfamily