Fbln5 fibulin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbln5provided by RGD
Official Full Name: fibulin 5provided by RGD
Primary source: RGD:2594
See related: EnsemblRapid:ENSRNOG00000050539 AllianceGenome:RGD:2594
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable integrin binding activity and protein homodimerization activity. Involved in regulation of cell growth. Located in extracellular space. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 322.4), Spleen (RPKM 270.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (126664100..126742847, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (120899219..120977829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (125644797..125723957, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protease Inhibition Improves Healing of The Vaginal Wall after Obstetrical Injury: Results from a Preclinical Animal Model.
Title: Protease Inhibition Improves Healing of The Vaginal Wall after Obstetrical Injury: Results from a Preclinical Animal Model.
upregulation of fibulin-5 is involved in the beneficial effect of RIPostC against cerebral I/R injury
Title: Limb remote ischaemic postconditioning-induced elevation of fibulin-5 confers neuroprotection to rats with cerebral ischaemia/reperfusion injury: Activation of the AKT pathway.
Fibulin-5 overexpression attenuated reactive oxygen species expression, which in turn decreased apoptosis and blood-brain barrier (BBB) permeability following middle cerebral artery occlusion and reperfusion.
Title: Overexpression of Fibulin-5 Attenuates Ischemia/Reperfusion Injury After Middle Cerebral Artery Occlusion in Rats.
These results suggest that in an indirect co-culture system, pelvic ligament fibroblasts with mechanical stretch stimulation can promote bone mesenchymal stem cell differentiation, reflecting in the increased expression of elastin, LOX, and Fibulin-5.
Title: Effect of mechanical stretch on the expressions of elastin, LOX and Fibulin-5 in rat BMSCs with ligament fibroblasts co-culture.
Fibulin-5 plays a role not only in the tissue repair and remodelling after renal tubular oxidative damage but also in renal cell carcinoma metastasis, presumably as a cytokine.
Title: Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133848 (e-PCR)
- UniSTS:217131

D6Hmgc5 (e-PCR)
- UniSTS:530828

D6Hmgc15 (e-PCR)
- UniSTS:530837

AU047432 (e-PCR)
- UniSTS:110515

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in elastic fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in elastic fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in intramembranous bone growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in secretion	IEA Inferred from Electronic Annotation more info
involved_in secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in elastic fiber	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibulin-5

Names: EVEC; FIBL-5; dance; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF repeat-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019153.4 → NP_062026.2 fibulin-5 precursor

See identical proteins and their annotated locations for NP_062026.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q9R284, Q9WVH8

UniProtKB/TrEMBL

A0A8L2R0X2, A6JEJ1

Related

ENSRNOP00000007004.7, ENSRNOT00000007004.9

Conserved Domains (4) summary

smart00179
Location:207 → 245

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:187 → 210

cEGF; Complement Clr-like EGF-like

pfam14670
Location:258 → 286

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:121 → 165

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

126664100..126742847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240459.5 → XP_006240521.1 fibulin-5 isoform X1

UniProtKB/TrEMBL

A0A8I6AHX3

Related

ENSRNOP00000093087.2, ENSRNOT00000111088.2

Conserved Domains (4) summary

smart00179
Location:220 → 258

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:200 → 223

cEGF; Complement Clr-like EGF-like

pfam14670
Location:271 → 299

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:134 → 178

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_063261574.1 → XP_063117644.1 fibulin-5 isoform X2