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    Gusb glucuronidase, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gusbprovided by RGD
    Official Full Name
    glucuronidase, betaprovided by RGD
    Primary source
    RGD:2772
    See related
    EnsemblRapid:ENSRNOG00000000913 AllianceGenome:RGD:2772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gus-s; Ac2-223
    Summary
    Enables beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in chondroitin sulfate catabolic process; heparan sulfate proteoglycan catabolic process; and hyaluronan catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space and lysosomal lumen. Biomarker of mucopolysaccharidosis and peritonitis. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 160.6), Liver (RPKM 123.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gusb in Genome Data Viewer
    Location:
    12q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32337281..32350838)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26701188..26714718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30202066..30215583)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene ribosomal protein S9, pseudogene 15 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 Neighboring gene transfer RNA alanine (anticodon AGC) 84 Neighboring gene nuclear protein 2, transcriptional regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Actinomycin D peritonitis in the rat. Arrigoni-Martelli E. Fed Proc, 1976 Nov. PMID 185091
    2. Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat. Sofia DR, et al. Agents Actions, 1976 Nov. PMID 827200
    3. The suramin-treated rat as a model of mucopolysaccharidosis. Variation in the reversibility of biochemical and morphological changes among different organs. Rees S, et al. Virchows Arch B Cell Pathol Incl Mol Pathol, 1986. PMID 2879381
    4. Rat liver beta-glucuronidase. cDNA cloning, sequence comparisons and expression of a chimeric protein in COS cells. Powell PP, et al. Biochem J, 1988 Mar 1. PMID 3355537, Free PMC Article
    5. Nucleotide sequence of rat preputial gland beta-glucuronidase cDNA and in vitro insertion of its encoded polypeptide into microsomal membranes. Nishimura Y, et al. Proc Natl Acad Sci U S A, 1986 Oct. PMID 3463967, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest beta-glucuronidase and bilitranslocase in vascular endothelium are involved in changes in endothelium-independent vaso-relaxation induced by dietary antioxidants; here, using in vitro studies with thoracic aorta rings in oxidative stress, glucuronides of dietary supplement antioxidant hydroxytyrosol (HT) are deconjugated by beta-glucuronidase before HT is taken up by vascular endothelium via bilitranslocase.
      Title: Involvement of bilitranslocase and beta-glucuronidase in the vascular protection by hydroxytyrosol and its glucuronide metabolites in oxidative stress conditions.
    2. Elucidation of the mechanism of increased beta-glucuronidase in the serum during hepatic fibrosis.
      Title: Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.
    3. Gusb may inhibit the formation of pure cholesterol gall stones.
      Title: Inhibition of cholesterol crystallization under bilirubin deconjugation: partial characterization of mechanisms whereby infected bile accelerates pigment stone formation.
    4. The presence of O-linked glycans and branched N-linked glycans in microsomal beta-glucuronidase
      Title: Characterization of the oligosaccharide component of microsomal beta-glucuronidase from rat liver.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-glucuronidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-glucuronidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-glucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-glucuronidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables beta-glucuronidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-glucuronidase
    NP_058711.3
    XP_017453744.1
    XP_063127108.1
    XP_063127109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017015.3 → NP_058711.3  beta-glucuronidase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P06760
      UniProtKB/TrEMBL
      F1LQQ8
      Related
      ENSRNOP00000001215.5, ENSRNOT00000001215.8
      Conserved Domains (1) summary
      cl30613
      Location:27 → 627
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32337281..32350838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271039.1 → XP_063127109.1  beta-glucuronidase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZP5
      Related
      ENSRNOP00000084597.1, ENSRNOT00000103940.2

    2. XM_063271038.1 → XP_063127108.1  beta-glucuronidase isoform X1

    3. XM_017598255.3 → XP_017453744.1  beta-glucuronidase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06760.1 GenPept UniProtKB/Swiss-Prot:P06760

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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