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    Lhcgr luteinizing hormone/choriogonadotropin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25477, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lhcgrprovided by RGD
    Official Full Name
    luteinizing hormone/choriogonadotropin receptorprovided by RGD
    Primary source
    RGD:3007
    See related
    EnsemblRapid:ENSRNOG00000016712 AllianceGenome:RGD:3007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lhr; LSHR; LSH-R; LH/CG-R
    Summary
    Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and positive regulation of calcium ion transmembrane transport. Located in endosome and extracellular space. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 193.3) and Uterus (RPKM 13.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lhcgr in Genome Data Viewer
    Location:
    6q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11415361..11480834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5661871..5728109)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12493182..12554482, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479269 Neighboring gene uncharacterized LOC134479270 Neighboring gene pyruvate kinase PKM-like Neighboring gene general transcription factor 2A subunit 1 like Neighboring gene uncharacterized LOC120103455 Neighboring gene stonin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choriogonadotropin hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables choriogonadotropin hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables choriogonadotropin hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choriogonadotropin hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables luteinizing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables luteinizing hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables luteinizing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables luteinizing hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonate secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to gonadotropin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to luteinizing hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to luteinizing hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to luteinizing hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in development of secondary male sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within development of secondary male sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in luteinizing hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in luteinizing hormone signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in luteinizing hormone signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in luteinizing hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovulation cycle process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ovulation cycle process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ovulation cycle process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of hormone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inositol trisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inositol trisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein targeting to lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of steroid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of steroid hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of steroid hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to luteinizing hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in seminiferous tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within uterus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lutropin-choriogonadotropic hormone receptor
    Names
    LH receptor
    LH/CG receptor
    luteinizing hormone receptor
    luteinizing hormone/chorionic gonadotropin receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433211.1NP_001420140.1  lutropin-choriogonadotropic hormone receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
    2. NM_012978.3NP_037110.1  lutropin-choriogonadotropic hormone receptor precursor

      See identical proteins and their annotated locations for NP_037110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P16235, P70646, Q63807, Q63808, Q63809, Q6LDI7
      UniProtKB/TrEMBL
      A6H9B2, F1LMG6
      Related
      ENSRNOP00000022481.6, ENSRNOT00000022481.9
      Conserved Domains (3) summary
      sd00033
      Location:5578
      LRR_RI; leucine-rich repeat [structural motif]
      cd15359
      Location:365638
      7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam13306
      Location:66204
      LRR_5; Leucine rich repeats (6 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      11415361..11480834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261562.1XP_063117632.1  lutropin-choriogonadotropic hormone receptor isoform X3

    2. XM_039111807.2XP_038967735.1  lutropin-choriogonadotropic hormone receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6GK42, F1LMG6
      Conserved Domains (3) summary
      sd00033
      Location:5377
      LRR_RI; leucine-rich repeat [structural motif]
      cd15359
      Location:339612
      7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam13306
      Location:40178
      LRR_5; Leucine rich repeats (6 copies)
    3. XM_039111808.2XP_038967736.1  lutropin-choriogonadotropic hormone receptor isoform X2

      Conserved Domains (1) summary
      cd15359
      Location:149422
      7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors