Fhl2 four and a half LIM domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fhl2provided by RGD
Official Full Name: four and a half LIM domains 2provided by RGD
Primary source: RGD:61963
See related: EnsemblRapid:ENSRNOG00000016866 AllianceGenome:RGD:61963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLIM 3
Summary: Predicted to enable bHLH transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of calcineurin-NFAT signaling cascade. Located in M band and Z disc. Orthologous to human FHL2 (four and a half LIM domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 2902.9) and Kidney (RPKM 149.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (52881091..52954540, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (45388979..45462421, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (49920611..49994906, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
Title: CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply.
Title: FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply.
FHL2 is involved in renal interstitial fibrosis by altering the phenotype of renal tubular epithelial cells via regulating the beta-catenin pathway.
Title: FHL2 participates in renal interstitial fibrosis by altering the phenotype of renal tubular epithelial cells via regulating the β-catenin pathway.
This study illustrated the FHL2-driven molecular network controlling SEPT2-mediated apoptosis in mesangial cell and their potential roles in mesangial proliferative nephritis.
Title: FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell.
FHL2 inhibits hypertrophic growth induced by calcineurin in neonatal rat ventricular myocytes.
Title: FHL2 binds calcineurin and represses pathological cardiac growth.
FHL2 overexpression induced mesangial cell proliferation by increasing the number of S-phase cells and decreasing G2/M-phase cells, whereas inhibiting FHL2 had the opposite effect
Title: Bioinformatics analysis of proteomic profiles during the process of anti-Thy1 nephritis.
FHL2 regulates serum response factor-dependent transcription by multiple mechanisms
Title: Regulation of myocardin factor protein stability by the LIM-only protein FHL2.
role in subcellular targeting of metabolic enzymes to titin in heart muscle
Title: Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in atrial cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in atrial cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	IEA Inferred from Electronic Annotation more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: four and a half LIM domains protein 2

Names: LIM domain protein DRAL; skeletal muscle LIM-protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412599.1 → NP_001399528.1 four and a half LIM domains protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O35115

UniProtKB/TrEMBL

A0A8I6A8C5, A6INR3

Related

ENSRNOP00000088694.2, ENSRNOT00000101412.2
NM_031677.2 → NP_113865.1 four and a half LIM domains protein 2

See identical proteins and their annotated locations for NP_113865.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O35115

UniProtKB/TrEMBL

A0A8I6A8C5, A6INR3

Related

ENSRNOP00000084804.2, ENSRNOT00000114387.2

Conserved Domains (3) summary

cd09426
Location:101 → 157

LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)

cd09433
Location:221 → 278

LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)

cl02475
Location:36 → 97

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

52881091..52954540 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084158.2 → XP_038940086.1 four and a half LIM domains protein 2 isoform X1

UniProtKB/Swiss-Prot

O35115

UniProtKB/TrEMBL

A0A8I6A8C5, A6INR3

Conserved Domains (3) summary

cd09426
Location:101 → 157

LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)

cd09433
Location:221 → 278

LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)

cl02475
Location:36 → 97

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers