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    Tnpo2 transportin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnpo2provided by RGD
    Official Full Name
    transportin 2provided by RGD
    Primary source
    RGD:1310356
    See related
    EnsemblRapid:ENSRNOG00000003970 AllianceGenome:RGD:1310356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to human TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 248.8), Thymus (RPKM 226.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnpo2 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40004271..40024565, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23099398..23119696, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26149671..26171812)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 14 Neighboring gene F-box and WD repeat domain containing 9 Neighboring gene small nucleolar RNA ZL2 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene telomerase RNA component interacting RNase Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. van der Giessen K, et al. Mol Biol Cell, 2007 Jul. PMID 17475777, Free PMC Article
    2. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    3. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transportin-2
    Names
    transportin 2 (importin 3, karyopherin beta 2b)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107166.1 → NP_001100636.1  transportin-2

      See identical proteins and their annotated locations for NP_001100636.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A8I6AJ53, A6IY37
      Related
      ENSRNOP00000005571.7, ENSRNOT00000005571.8
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40004271..40024565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277973.1 → XP_063134043.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJ53

    2. XM_017601260.3 → XP_017456749.1  transportin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ53, D3ZER6

    3. XM_017601259.3 → XP_017456748.1  transportin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ53, D3ZER6

    4. XM_017601261.3 → XP_017456750.1  transportin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ53, D3ZER6

    5. XM_017601258.3 → XP_017456747.1  transportin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJ53, D3ZER6

    6. XM_017601263.3 → XP_017456752.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJ53
      Related
      ENSRNOP00000094245.1, ENSRNOT00000119606.2
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    7. XM_063277974.1 → XP_063134044.1  transportin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJ53, A6IY37

    8. XM_017601264.3 → XP_017456753.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJ53
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    9. XM_039097687.2 → XP_038953615.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJ53
      Conserved Domains (3) summary
      COG5215
      Location:103 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:5 → 33
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:52 → 132
      HEAT_2; HEAT repeats
    Nucleotide Protein Strain
    Heading Accession and Version

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