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    Pgs1 phosphatidylglycerophosphate synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303698, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pgs1provided by RGD
    Official Full Name
    phosphatidylglycerophosphate synthase 1provided by RGD
    Primary source
    RGD:1305052
    See related
    EnsemblRapid:ENSRNOG00000002949 AllianceGenome:RGD:1305052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305052
    Summary
    Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 110.2), Lung (RPKM 103.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgs1 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103713306..103748924)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103214635..103250254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106994595..107030208)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095340 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene uncharacterized LOC120095221 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene uncharacterized LOC134480725

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Peyta L, et al. Biochim Biophys Acta, 2015 Nov. PMID 26327596
    2. Metabolism and function of mitochondrial cardiolipin. Ren M, et al. Prog Lipid Res, 2014 Jul. PMID 24769127
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
    NP_001414415.1
    XP_006247917.1
    XP_038943442.1
    XP_063125311.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427486.1 → NP_001414415.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HL41, D4A5W8
      Related
      ENSRNOP00000004007.7, ENSRNOT00000004007.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103713306..103748924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247855.5 → XP_006247917.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247917.1

      UniProtKB/TrEMBL
      A0A8I6ACK5, A6HL41, D4A5W8
      Conserved Domains (2) summary
      cd09135
      Location:93 → 266
      PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
      cd09137
      Location:346 → 505
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

    2. XM_063269241.1 → XP_063125311.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X2

      Related
      ENSRNOP00000100202.1, ENSRNOT00000172364.1

    3. XM_039087514.2 → XP_038943442.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X3

      Conserved Domains (2) summary
      cd09137
      Location:168 → 327
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
      cl15239
      Location:1 → 88
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RNA

    1. XR_010055194.1 RNA Sequence

    2. XR_010055193.1 RNA Sequence

    3. XR_010055192.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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