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    Ube2l3 ubiquitin-conjugating enzyme E2L 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2l3provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2L 3provided by RGD
    Primary source
    RGD:1308361
    See related
    EnsemblRapid:ENSRNOG00000001862 AllianceGenome:RGD:1308361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UbcH7; UbcR7
    Summary
    Predicted to enable several functions, including ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in several processes, including positive regulation of protein targeting to mitochondrion; positive regulation of ubiquitin-protein transferase activity; and protein K11-linked ubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Located in presynapse. Orthologous to human UBE2L3 (ubiquitin conjugating enzyme E2 L3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 290.4), Kidney (RPKM 289.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2l3 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97300584..97343084)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83797722..83838862)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88047186..88088477)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene HIC ZBTB transcriptional repressor 2 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene RIMS binding protein 3 Neighboring gene small nucleolar RNA SNORA51 Neighboring gene YdjC chitooligosaccharide deacetylase homolog Neighboring gene coiled-coil domain containing 116 Neighboring gene stromal cell-derived factor 2-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain. Wang M, et al. J Neurochem, 2001 Jun. PMID 11413239
    2. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. Whitcomb EA, et al. Mol Biol Cell, 2009 Jan. PMID 18946090, Free PMC Article
    3. Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4. Moynihan TP, et al. Mamm Genome, 1999 Oct. PMID 10501966
    4. Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. Lonskaya I, et al. J Mol Med (Berl), 2014 Apr. PMID 24337465, Free PMC Article
    5. UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. Garside H, et al. J Endocrinol, 2006 Sep. PMID 17003263

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to steroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 L3
    NP_001316065.1
    XP_038944475.1
    XP_063126745.1
    XP_063126746.1
    XP_063126747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329136.1 → NP_001316065.1  ubiquitin-conjugating enzyme E2 L3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      B2RZA9, D3Z8W5
      Related
      ENSRNOP00000050143.5, ENSRNOT00000046159.6
      Conserved Domains (1) summary
      smart00212
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97300584..97343084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088547.2 → XP_038944475.1  ubiquitin-conjugating enzyme E2 L3 isoform X2

      UniProtKB/TrEMBL
      B2RZA9, D3Z8W5
      Conserved Domains (1) summary
      smart00212
      Location:6 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. XM_063270677.1 → XP_063126747.1  ubiquitin-conjugating enzyme E2 L3 isoform X4

      Related
      ENSRNOP00000100197.1, ENSRNOT00000169448.1

    3. XM_063270675.1 → XP_063126745.1  ubiquitin-conjugating enzyme E2 L3 isoform X1

    4. XM_063270676.1 → XP_063126746.1  ubiquitin-conjugating enzyme E2 L3 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108847.1: Suppressed sequence

      Description
      NM_001108847.1: This RefSeq was removed because it was annotated with an incorrect coding sequence.
    Nucleotide Protein Strain
    Heading Accession and Version

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