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    Ap1ar adaptor-related protein complex 1 associated regulatory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap1arprovided by RGD
    Official Full Name
    adaptor-related protein complex 1 associated regulatory proteinprovided by RGD
    Primary source
    RGD:1311435
    See related
    EnsemblRapid:ENSRNOG00000024492 AllianceGenome:RGD:1311435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311435
    Summary
    Predicted to enable AP-1 adaptor complex binding activity and kinesin binding activity. Predicted to be involved in negative regulation of receptor recycling and vesicle targeting, trans-Golgi to endosome. Predicted to act upstream of or within several processes, including negative regulation of cell motility; negative regulation of substrate adhesion-dependent cell spreading; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in Golgi apparatus and transport vesicle. Predicted to be active in endosome. Orthologous to human AP1AR (adaptor related protein complex 1 associated regulatory protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 91.7), Liver (RPKM 71.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap1ar in Genome Data Viewer
    Location:
    2q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218951104..218983495, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (216276631..216309020, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (232146418..232178813, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene ribosomal protein L29, pseudogene 5 Neighboring gene TRAF-interacting protein with forkhead-associated domain Neighboring gene transfer RNA alanine (anticodon AGC) 70 Neighboring gene family with sequence similarity 241 member A Neighboring gene uncharacterized LOC120101099

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. Schmidt MR, et al. Proc Natl Acad Sci U S A, 2009 Sep 8. PMID 19706427, Free PMC Article
    2. Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Maritzen T, et al. Proc Natl Acad Sci U S A, 2012 Jun 26. PMID 22689987, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AP-1 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle targeting, trans-Golgi to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle targeting, trans-Golgi to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex-associated regulatory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191850.1 → NP_001178779.1  AP-1 complex-associated regulatory protein

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (1) summary
      pfam15745
      Location:26 → 300
      AP1AR; AP-1 complex-associated regulatory protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218951104..218983495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102717.2 → XP_038958645.1  AP-1 complex-associated regulatory protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0K6
      Conserved Domains (1) summary
      pfam15745
      Location:24 → 265
      AP1AR; AP-1 complex-associated regulatory protein

    2. XM_006233291.5 → XP_006233353.4  AP-1 complex-associated regulatory protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5I3, F1M9P0
      Related
      ENSRNOP00000104283.1, ENSRNOT00000139033.1
      Conserved Domains (1) summary
      pfam15745
      Location:24 → 298
      AP1AR; AP-1 complex-associated regulatory protein

    3. XM_063282219.1 → XP_063138289.1  AP-1 complex-associated regulatory protein isoform X6

    4. XM_063282218.1 → XP_063138288.1  AP-1 complex-associated regulatory protein isoform X5

    5. XM_039102719.2 → XP_038958647.1  AP-1 complex-associated regulatory protein isoform X4

      Conserved Domains (1) summary
      pfam15745
      Location:2 → 207
      AP1AR; AP-1 complex-associated regulatory protein

    6. XM_039102718.2 → XP_038958646.1  AP-1 complex-associated regulatory protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5I3
      Related
      ENSRNOP00000088649.2, ENSRNOT00000109329.2
      Conserved Domains (1) summary
      pfam15745
      Location:2 → 240
      AP1AR; AP-1 complex-associated regulatory protein
    Nucleotide Protein Strain
    Heading Accession and Version

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