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    Msl1 MSL complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303514, updated on 9-Dec-2024

    Summary

    Official Symbol
    Msl1provided by RGD
    Official Full Name
    MSL complex subunit 1provided by RGD
    Primary source
    RGD:1564778
    See related
    EnsemblRapid:ENSRNOG00000009643 AllianceGenome:RGD:1564778
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564778
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in chromatin remodeling and positive regulation of DNA-templated transcription. Predicted to be located in nuclear speck. Predicted to be part of MSL complex. Orthologous to human MSL1 (MSL complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 247.2), Brain (RPKM 214.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Msl1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84251362..84263384)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83755380..83767147)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86710925..86722659)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor alpha Neighboring gene uncharacterized LOC108352130 Neighboring gene nuclear receptor subfamily 1, group D, member 1 Neighboring gene CASC3 exon junction complex subunit Neighboring gene Rap guanine nucleotide exchange factor like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    male-specific lethal 1 homolog
    Names
    male specific lethal 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107048.1NP_001100518.1  male-specific lethal 1 homolog

      See identical proteins and their annotated locations for NP_001100518.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIV1, D3ZBD0
      Related
      ENSRNOP00000012812.5, ENSRNOT00000012812.9
      Conserved Domains (1) summary
      pfam15275
      Location:460576
      PEHE; PEHE domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84251362..84263384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247304.5XP_006247366.1  male-specific lethal 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006247366.1

      UniProtKB/TrEMBL
      A0A8I5ZM69, A6HIV0
      Related
      ENSRNOP00000079028.1, ENSRNOT00000107825.2
      Conserved Domains (1) summary
      pfam15275
      Location:476592
      PEHE; PEHE domain