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    Hand2 heart and neural crest derivatives expressed 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64637, updated on 27-Nov-2024

    Summary

    Symbol
    Hand2provided by RGD
    Full Name
    heart and neural crest derivatives expressed 2provided by RGD
    Primary source
    RGD:621207
    See related
    EnsemblRapid:ENSRNOG00000060448 AllianceGenome:RGD:621207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in cellular response to organic cyclic compound; cellular response to retinoic acid; and heart development. Predicted to be located in chromatin and nucleus. Predicted to be part of transcription regulator complex. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 128.0), Adrenal (RPKM 49.3) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hand2 in Genome Data Viewer
    Location:
    16p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (37928145..37931488, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (32917448..32920791, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (36371489..36373551, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482495 Neighboring gene uncharacterized LOC103693946 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene 60S ribosomal protein L7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables E-box binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables minor groove of adenine-thymine-rich DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables minor groove of adenine-thymine-rich DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac neural crest cell development involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac right ventricle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac right ventricle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cartilage morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cartilage morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell proliferation involved in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell proliferation involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in coronary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of heart left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesenchyme development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect norepinephrine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peripheral nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peripheral nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of semaphorin-plexin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in primary palate development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within primary palate development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of secondary heart field cardioblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of secondary heart field cardioblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in suckling behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within suckling behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sympathetic nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sympathetic nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tongue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tongue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visceral serous pericardium development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visceral serous pericardium development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heart- and neural crest derivatives-expressed protein 2
    Names
    dHand protein
    deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2
    heart and neural crest derivatives expressed transcript 2
    heart- and neural crest derivatives-expressed protein 2-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022696.2NP_073187.1  heart- and neural crest derivatives-expressed protein 2

      See identical proteins and their annotated locations for NP_073187.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P61295
      Related
      ENSRNOP00000074299.2, ENSRNOT00000079552.3
      Conserved Domains (1) summary
      cd11471
      Location:100161
      bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      37928145..37931488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)