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    Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arih1provided by RGD
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1308131
    See related
    EnsemblRapid:ENSRNOG00000009887 AllianceGenome:RGD:1308131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 246.2), Adrenal (RPKM 225.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arih1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (68673199..68775648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (59777378..59879762, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64166359..64268555, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ribosomal protein L13, pseudogene 16 Neighboring gene cyclin-dependent kinases regulatory subunit 2-like Neighboring gene small nucleolar RNA SNORA40 Neighboring gene transmembrane protein 202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies. Elmehdawi F, et al. Exp Cell Res, 2013 Feb 1. PMID 23059369
    2. Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Duda DM, et al. Structure, 2013 Jun 4. PMID 23707686, Free PMC Article
    3. Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. Capili AD, et al. J Mol Biol, 2004 Jul 23. PMID 15236971
    4. The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies. Parelkar SS, et al. J Mol Neurosci, 2012 Jan. PMID 21590270
    5. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. Tan NG, et al. FEBS Lett, 2003 Nov 20. PMID 14623119

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Lewy body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH1
    Names
    ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1
    ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
    NP_001013126.2
    XP_063121197.1
    XP_063121198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013108.3 → NP_001013126.2  E3 ubiquitin-protein ligase ARIH1

      See identical proteins and their annotated locations for NP_001013126.2

      Status: VALIDATED

      Source sequence(s)
      AW141789, BC083881, CA339823, CK478034, CN544531, CV126532, DN956151, DV714248, DY312590
      UniProtKB/TrEMBL
      D3ZXL1
      Related
      ENSRNOP00000081863.2, ENSRNOT00000098010.2
      Conserved Domains (3) summary
      smart00647
      Location:255 → 315
      IBR; In Between Ring fingers
      cd16626
      Location:183 → 240
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:337 → 377
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      68673199..68775648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265127.1 → XP_063121197.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A015

    2. XM_063265128.1 → XP_063121198.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEU5, Q5XI15
      Related
      ENSRNOP00000075350.1, ENSRNOT00000084758.3
    Nucleotide Protein Strain
    Heading Accession and Version

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