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    Fbxo11 F-box protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301674, updated on 27-Nov-2024

    Summary

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    Symbol
    Fbxo11provided by RGD
    Full Name
    F-box protein 11provided by RGD
    Primary source
    RGD:727935
    See related
    EnsemblRapid:ENSRNOG00000016396 AllianceGenome:RGD:727935
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vit1
    Summary
    Predicted to enable protein-arginine N-methyltransferase activity; ubiquitin-like ligase-substrate adaptor activity; and ubiquitin-protein transferase activity. Involved in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel and positive regulation of protein catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 130.9), Spleen (RPKM 100.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo11 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12240348..12316223)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (6486761..6562664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11662356..11737427, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 1, pseudogene 2 Neighboring gene uncharacterized LOC120103457 Neighboring gene uncharacterized LOC120103458 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 3 Neighboring gene uncharacterized LOC134479271 Neighboring gene mutS homolog 6 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene uncharacterized LOC120103460

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miR-324-5p upregulation potentiates resistance to cisplatin by targeting FBXO11 signalling in non-small cell lung cancer cells. Ba Z, et al. J Biochem, 2019 Dec 1. PMID 31778188
    2. Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes. Ma XE, et al. Channels (Austin), 2020 Dec. PMID 32988261, Free PMC Article
    3. LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer. Zhang Y, et al. Cell Biol Int, 2020 Mar. PMID 31829474
    4. F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. Sun C, et al. Biomed Pharmacother, 2018 Feb. PMID 29278851
    5. A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. Hardisty-Hughes RE, et al. Hum Mol Genet, 2006 Nov 15. PMID 17035249

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 11
    Names
    F-box only protein 11-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181631.2 → NP_853662.1  F-box only protein 11

      See identical proteins and their annotated locations for NP_853662.1

      Status: PROVISIONAL

      Source sequence(s)
      AY274810
      UniProtKB/Swiss-Prot
      Q7TSL3
      UniProtKB/TrEMBL
      A6H9C5
      Related
      ENSRNOP00000110764.1, ENSRNOT00000165520.1
      Conserved Domains (3) summary
      pfam12937
      Location:73 → 116
      F-box-like
      pfam13229
      Location:580 → 739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766 → 807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      12240348..12316223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112126.2 → XP_038968054.1  F-box only protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QBJ7
      Related
      ENSRNOP00000021998.5, ENSRNOT00000021998.7
      Conserved Domains (3) summary
      pfam12937
      Location:163 → 206
      F-box-like
      pfam13229
      Location:670 → 829
      Beta_helix; Right handed beta helix region
      cl19744
      Location:856 → 897
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    2. XM_039112127.2 → XP_038968055.1  F-box only protein 11 isoform X2

      Conserved Domains (3) summary
      pfam12937
      Location:162 → 205
      F-box-like
      pfam13229
      Location:669 → 828
      Beta_helix; Right handed beta helix region
      cl19744
      Location:855 → 896
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    3. XM_017594113.3 → XP_017449602.1  F-box only protein 11 isoform X4

      UniProtKB/Swiss-Prot
      Q7TSL3
      UniProtKB/TrEMBL
      A6H9C5
      Conserved Domains (3) summary
      pfam12937
      Location:73 → 116
      F-box-like
      pfam13229
      Location:580 → 739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766 → 807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    4. XM_063261802.1 → XP_063117872.1  F-box only protein 11 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSL3.1 GenPept UniProtKB/Swiss-Prot:Q7TSL3

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