Meg3 maternally expressed 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Meg3provided by RGD
Official Full Name: maternally expressed 3provided by RGD
Primary source: RGD:1566401
See related: AllianceGenome:RGD:1566401
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gtl2; RGD1566401
Summary: Predicted to enable dsDNA-RNA triple helix-forming chromatin adaptor activity. Predicted to be involved in chromatin organization. Predicted to act upstream of or within several processes, including determination of adult lifespan; epigenetic programming of gene expression; and lung alveolus development. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 748.0), Brain (RPKM 574.0) and 1 other tissue See more
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Genomic context

Location:: 6q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (134274056..134306249)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (128491808..128524010)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (133658937..133691130)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA Meg3 Aggravates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Rats by Activating the Hedgehog Pathway.
Title: LncRNA Meg3 Aggravates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Rats by Activating the Hedgehog Pathway.
LncRNA MEG3 promotes neuronal apoptosis in rats with ischemic cerebral infarction via the TGF-beta1 pathway.
Title: LncRNA MEG3 promotes neuronal apoptosis in rats with ischemic cerebral infarction via the TGF-β1 pathway.
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
Title: Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
LncRNA MEG3-TRPV1 signaling regulates chronic inflammatory pain in rats.
Title: LncRNA MEG3-TRPV1 signaling regulates chronic inflammatory pain in rats.
LncRNA-MEG3 attenuates hyperglycemia-induced damage by enhancing mitochondrial translocation of HSP90A in the primary hippocampal neurons.
Title: LncRNA-MEG3 attenuates hyperglycemia-induced damage by enhancing mitochondrial translocation of HSP90A in the primary hippocampal neurons.
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p.
Title: Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p.
Tensile strain promotes osteogenic differentiation of bone marrow mesenchymal stem cells through upregulating lncRNA-MEG3.
Title: Tensile strain promotes osteogenic differentiation of bone marrow mesenchymal stem cells through upregulating lncRNA-MEG3.
lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis.
Title: lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis.
Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR-98-5p-Sponged IL-10.
Title: Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR-98-5p-Sponged IL-10.
Over-expression of MEG3 promotes differentiation of bone marrow mesenchymal stem cells into chondrocytes by regulating miR-129-5p/RUNX1 axis.
Title: Over-expression of MEG3 promotes differentiation of bone marrow mesenchymal stem cells into chondrocytes by regulating miR-129-5p/RUNX1 axis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

D12Bwg1266e (e-PCR), detects polymorphism
- UniSTS:141840

RH131086 (e-PCR)
- UniSTS:214369

RH142531 (e-PCR)
- UniSTS:231778

RH135450 (e-PCR)
- UniSTS:218727

PMC133956P1 (e-PCR)
- UniSTS:270696

BE115920 (e-PCR)
- UniSTS:248245

RH144192 (e-PCR)
- UniSTS:233438

AW532640 (e-PCR)
- UniSTS:260574

BI283861 (e-PCR)
- UniSTS:243680

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dsDNA-RNA triple helix-forming chromatin adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epigenetic programing of female pronucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within genomic imprinting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.