Lhfpl4 LHFPL tetraspan subfamily member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Lhfpl4provided by RGD
Full Name: LHFPL tetraspan subfamily member 4provided by RGD
Primary source: RGD:727967
See related: EnsemblRapid:ENSRNOG00000091268 AllianceGenome:RGD:727967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity. Predicted to be involved in protein localization to membrane; regulation of inhibitory synapse assembly; and sensory perception of sound. Located in inhibitory synapse. Orthologous to human LHFPL4 (LHFPL tetraspan subfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 71.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (147872877..147895770, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146317110..146340073, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145117533..145147397, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results establish LHFPL4 as a synapse-specific tetraspanin essential for inhibitory synapse function and provide fresh insights into the molecular make-up of inhibitory synapses.
Title: An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABA(A) Receptors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in inhibitory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: LHFPL tetraspan subfamily member 4 protein

Names: HMGIC fusion partner-like protein 4; lipoma HMGIC fusion partner-like 4 protein; lipoma HMGIC fusion partner-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181387.4 → NP_852052.3 LHFPL tetraspan subfamily member 4 protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q7TSY2

UniProtKB/TrEMBL

A6IBP5

Related

ENSRNOP00000110268.1, ENSRNOT00000164144.1