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    Txndc16 thioredoxin domain containing 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361025, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Txndc16provided by RGD
    Official Full Name
    thioredoxin domain containing 16provided by RGD
    Primary source
    RGD:1306755
    See related
    EnsemblRapid:ENSRNOG00000006334 AllianceGenome:RGD:1306755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306755
    Summary
    Predicted to be located in endoplasmic reticulum lumen. Orthologous to human TXNDC16 (thioredoxin domain containing 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 125.3), Spleen (RPKM 125.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Txndc16 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (20831541..20905661, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18351688..18425833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19472522..19547384, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482089 Neighboring gene uncharacterized LOC120096941 Neighboring gene uncharacterized LOC120096942 Neighboring gene prostaglandin E receptor 2 Neighboring gene ribosomal protein S10 like 6 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2, pseudogene 1 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. Riemer J, et al. PLoS One, 2011 Feb 16. PMID 21359175, Free PMC Article
    2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427814.1 → NP_001414743.1  thioredoxin domain-containing protein 16

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3ZQK4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      20831541..20905661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274391.1 → XP_063130461.1  thioredoxin domain-containing protein 16 isoform X2

      UniProtKB/TrEMBL
      A6KDZ1

    2. XM_039093784.2 → XP_038949712.1  thioredoxin domain-containing protein 16 isoform X1

      UniProtKB/TrEMBL
      D3ZQK4
      Conserved Domains (3) summary
      cd02961
      Location:429 → 527
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:173 → 527
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:568 → 757
      Thioredoxin_6; Thioredoxin-like domain

    3. XM_039093785.2 → XP_038949713.1  thioredoxin domain-containing protein 16 isoform X2

      UniProtKB/TrEMBL
      A6KDZ1
      Related
      ENSRNOP00000008372.9, ENSRNOT00000008372.9
      Conserved Domains (3) summary
      cd02961
      Location:429 → 527
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:173 → 527
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:568 → 757
      Thioredoxin_6; Thioredoxin-like domain

    4. XM_039093786.2 → XP_038949714.1  thioredoxin domain-containing protein 16 isoform X4

      Conserved Domains (3) summary
      cd02961
      Location:218 → 316
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      TIGR01130
      Location:66 → 316
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      pfam13848
      Location:357 → 546
      Thioredoxin_6; Thioredoxin-like domain

    5. XM_063274392.1 → XP_063130462.1  thioredoxin domain-containing protein 16 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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