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    Mrap melanocortin 2 receptor accessory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288271, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrapprovided by RGD
    Official Full Name
    melanocortin 2 receptor accessory proteinprovided by RGD
    Primary source
    RGD:1310648
    See related
    EnsemblRapid:ENSRNOG00000021524 AllianceGenome:RGD:1310648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310648
    Summary
    Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; protein localization to plasma membrane; and regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 1005.2) and Kidney (RPKM 48.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrap in Genome Data Viewer
    Location:
    11q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (43477382..43489118)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (29991974..30003024)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (30904733..30915225)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095608 Neighboring gene MIS18 kinetochore protein A Neighboring gene URB1 ribosome biogenesis homolog Neighboring gene uncharacterized LOC134481053 Neighboring gene eva-1 homolog C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Sebag JA, et al. Proc Natl Acad Sci U S A, 2007 Dec 18. PMID 18077336, Free PMC Article
    2. Melanocortin receptors and their accessory proteins. Cooray SN, et al. Mol Cell Endocrinol, 2011 Jan 15. PMID 20654690
    3. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sebag JA, et al. Sci Signal, 2010 Apr 6. PMID 20371771, Free PMC Article
    4. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Chan LF, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19329486, Free PMC Article
    5. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Wu Y, et al. Am J Physiol Endocrinol Metab, 2008 Jul. PMID 18492766, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables corticotropin hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables corticotropin hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 1 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 1 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 3 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 3 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 4 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 4 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type 5 melanocortin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type 5 melanocortin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanocortin-2 receptor accessory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135834.1 → NP_001129306.1  melanocortin-2 receptor accessory protein

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      D4A897
      Related
      ENSRNOP00000102102.1, ENSRNOT00000127610.1
      Conserved Domains (1) summary
      pfam15183
      Location:1 → 89
      MRAP; Melanocortin-2 receptor accessory protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      43477382..43489118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270431.1 → XP_063126501.1  melanocortin-2 receptor accessory protein isoform X1

    2. XM_039088214.2 → XP_038944142.1  melanocortin-2 receptor accessory protein isoform X2

      Conserved Domains (1) summary
      pfam15183
      Location:39 → 73
      MRAP; Melanocortin-2 receptor accessory protein family

    3. XM_039088215.2 → XP_038944143.1  melanocortin-2 receptor accessory protein isoform X3

      Conserved Domains (1) summary
      pfam15183
      Location:39 → 105
      MRAP; Melanocortin-2 receptor accessory protein family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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