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    St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St3gal1provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by RGD
    Primary source
    RGD:1309373
    See related
    EnsemblRapid:ENSRNOG00000008209 AllianceGenome:RGD:1309373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat4a
    Summary
    Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Predicted to be active in membrane. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 236.3), Spleen (RPKM 204.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St3gal1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (100734300..100802443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (98845270..98913409, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (107895045..107963158, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene N-myc downstream regulated 1 Neighboring gene uncharacterized LOC102550354 Neighboring gene uncharacterized LOC134479742 Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene uncharacterized LOC134479743

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural insight into mammalian sialyltransferases. Rao FV, et al. Nat Struct Mol Biol, 2009 Nov. PMID 19820709
    2. Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif. Jeanneau C, et al. J Biol Chem, 2004 Apr 2. PMID 14722111
    3. Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. Lee YC, et al. Eur J Biochem, 1993 Sep 1. PMID 8375377
    4. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. Martin LT, et al. J Biol Chem, 2002 Sep 6. PMID 12068010
    5. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi medial cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
    Names
    sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
    sialyltransferase ST3Gal-I
    NP_001013237.2
    XP_006241772.1
    XP_008763735.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013219.2 → NP_001013237.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q6H8N0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      100734300..100802443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765513.4 → XP_008763735.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_008763735.1

      UniProtKB/TrEMBL
      Q6H8N0
      Related
      ENSRNOP00000076083.3, ENSRNOT00000093353.3
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006241710.4 → XP_006241772.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006241772.1

      UniProtKB/TrEMBL
      Q6H8N0
      Conserved Domains (1) summary
      pfam00777
      Location:83 → 338
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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