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    Septin10 septin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin10provided by RGD
    Official Full Name
    septin 10provided by RGD
    Primary source
    RGD:1359307
    See related
    EnsemblRapid:ENSRNOG00000049507 AllianceGenome:RGD:1359307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sept10
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be located in sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 184.1), Adrenal (RPKM 66.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Septin10 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27644862..27737817, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27101764..27194997, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28722479..28814841, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 3 Neighboring gene leucine-rich repeat-containing protein 57-like Neighboring gene uncharacterized LOC134483910 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene small nuclear ribonucleoprotein D2-like Neighboring gene prolyl 4-hydroxylase subunit alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014033.1 → NP_001014055.1  septin-10

      See identical proteins and their annotated locations for NP_001014055.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087157
      UniProtKB/Swiss-Prot
      Q5PQK1
      UniProtKB/TrEMBL
      A0A0H2UI27
      Conserved Domains (3) summary
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21 → 393
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:337 → 393
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      27644862..27737817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256417.5 → XP_006256479.1  septin-10 isoform X3

      See identical proteins and their annotated locations for XP_006256479.1

      UniProtKB/TrEMBL
      A0A0H2UI27, A6K3U3
      Related
      ENSRNOP00000103161.1, ENSRNOT00000142196.1
      Conserved Domains (3) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:17 → 389
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:333 → 389
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_006256415.5 → XP_006256477.1  septin-10 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UI27
      Conserved Domains (3) summary
      cd01850
      Location:46 → 314
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:27 → 399
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:343 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. XM_017601667.3 → XP_017457156.1  septin-10 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UI27
      Related
      ENSRNOP00000073404.3, ENSRNOT00000086030.3

    4. XM_039098775.2 → XP_038954703.1  septin-10 isoform X5

      UniProtKB/TrEMBL
      A0A0H2UI27
      Related
      ENSRNOP00000091271.1, ENSRNOT00000112391.2
      Conserved Domains (2) summary
      cd01850
      Location:21 → 289
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:227 → 370
      DUF5401; Family of unknown function (DUF5401)

    5. XM_039098777.2 → XP_038954705.1  septin-10 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K5F4
      Conserved Domains (2) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:242 → 385
      DUF5401; Family of unknown function (DUF5401)

    6. XM_006256418.5 → XP_006256480.1  septin-10 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5F4
      Related
      ENSRNOP00000064265.4, ENSRNOT00000071663.4
      Conserved Domains (3) summary
      cd01850
      Location:46 → 314
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:27 → 399
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl20817
      Location:343 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. XM_063279185.1 → XP_063135255.1  septin-10 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K5F4

    8. XM_039098776.2 → XP_038954704.1  septin-10 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K5F4
      Conserved Domains (2) summary
      cd01850
      Location:40 → 308
      CDC_Septin; CDC/Septin GTPase family
      pfam17380
      Location:246 → 389
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQK1.1 GenPept UniProtKB/Swiss-Prot:Q5PQK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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