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    Tbrg4 transforming growth factor beta regulator 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360977, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbrg4provided by RGD
    Official Full Name
    transforming growth factor beta regulator 4provided by RGD
    Primary source
    RGD:1309737
    See related
    EnsemblRapid:ENSRNOG00000052477 AllianceGenome:RGD:1309737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial mRNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 108.5), Thymus (RPKM 105.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbrg4 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85696738..85704691, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81481977..81490781, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86876800..86885603, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene CCM2 scaffold protein Neighboring gene NAC alpha domain containing Neighboring gene small nucleolar RNA SNORA5 Neighboring gene small nucleolar RNA, H/ACA box 5C Neighboring gene whey acidic protein Neighboring gene receptor activity modifying protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain. Boehm E, et al. Nucleic Acids Res, 2017 Jun 2. PMID 28335001, Free PMC Article
    2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 4
    Names
    protein TBRG4
    transforming growth factor beta regulated gene 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012154.1 → NP_001012154.1  FAST kinase domain-containing protein 4

      See identical proteins and their annotated locations for NP_001012154.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087073
      UniProtKB/Swiss-Prot
      Q5M9G9
      Conserved Domains (3) summary
      smart00952
      Location:561 → 618
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 436
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:450 → 533
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      85696738..85704691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092225.2 → XP_038948153.1  FAST kinase domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A6IKV6, A6IKV7
      Conserved Domains (3) summary
      smart00952
      Location:468 → 525
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:275 → 343
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:357 → 440
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_006251343.5 → XP_006251405.1  FAST kinase domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006251405.1

      UniProtKB/Swiss-Prot
      Q5M9G9
      Conserved Domains (3) summary
      smart00952
      Location:561 → 618
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 436
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:450 → 533
      FAST_2; FAST kinase-like protein, subdomain 2

    3. XM_039092223.2 → XP_038948151.1  FAST kinase domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5M9G9
      Related
      ENSRNOP00000074223.1, ENSRNOT00000089133.3
      Conserved Domains (3) summary
      smart00952
      Location:561 → 618
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:368 → 436
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:450 → 533
      FAST_2; FAST kinase-like protein, subdomain 2

    4. XM_039092227.2 → XP_038948155.1  FAST kinase domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A6IKV7
      Conserved Domains (3) summary
      smart00952
      Location:301 → 358
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:108 → 176
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:190 → 273
      FAST_2; FAST kinase-like protein, subdomain 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M9G9.1 GenPept UniProtKB/Swiss-Prot:Q5M9G9

    Gene LinkOut

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