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    Rabggtb Rab geranylgeranyltransferase subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25533, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rabggtbprovided by RGD
    Official Full Name
    Rab geranylgeranyltransferase subunit betaprovided by RGD
    Primary source
    RGD:3530
    See related
    EnsemblRapid:ENSRNOG00000009992 AllianceGenome:RGD:3530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 515.3), Muscle (RPKM 394.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rabggtb in Genome Data Viewer
    Location:
    2q45
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245504586..245510878, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242844758..242850951, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260110309..260115574, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene mutS homolog 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134485696

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    geranylgeranyl transferase type-2 subunit beta
    Names
    GGTase-II-beta
    Rab geranylgeranyl transferase componenet, subunit beta
    Rab geranylgeranyltransferase, beta subunit
    geranylgeranyl transferase type II subunit beta
    rab GG transferase beta
    rab GGTase beta
    rab geranyl-geranyltransferase subunit beta
    type II protein geranyl-geranyltransferase subunit beta
    NP_619715.2
    XP_063137436.1
    XP_063137437.1
    XP_063137438.1
    XP_063137439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138708.3NP_619715.2  geranylgeranyl transferase type-2 subunit beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q08603
      UniProtKB/TrEMBL
      A0A8I6GFF2, A6HWN7, Q68G48
      Related
      ENSRNOP00000061541.3, ENSRNOT00000065997.3
      Conserved Domains (1) summary
      cd02894
      Location:18301
      GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      245504586..245510878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281366.1XP_063137436.1  geranylgeranyl transferase type-2 subunit beta isoform X1

      UniProtKB/Swiss-Prot
      Q08603
    2. XM_063281367.1XP_063137437.1  geranylgeranyl transferase type-2 subunit beta isoform X2

    3. XM_063281368.1XP_063137438.1  geranylgeranyl transferase type-2 subunit beta isoform X3

      UniProtKB/Swiss-Prot
      Q08603
      UniProtKB/TrEMBL
      A6HWN9
    4. XM_063281369.1XP_063137439.1  geranylgeranyl transferase type-2 subunit beta isoform X4

      UniProtKB/TrEMBL
      A6HWP3

    RNA

    1. XR_010063585.1 RNA Sequence