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    Fxyd3 FXYD domain-containing ion transport regulator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fxyd3provided by RGD
    Official Full Name
    FXYD domain-containing ion transport regulator 3provided by RGD
    Primary source
    RGD:620825
    See related
    EnsemblRapid:ENSRNOG00000080106 AllianceGenome:RGD:620825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MAT8
    Summary
    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Lung (RPKM 104.5), Brain (RPKM 31.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fxyd3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95432918..95440129, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86305531..86312455, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89502561..89510146, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene leucine-rich repeat LGI family, member 4 Neighboring gene uncharacterized LOC134483096 Neighboring gene hepsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FXYD3 (Mat-8), a new regulator of Na,K-ATPase. Crambert G, et al. Mol Biol Cell, 2005 May. PMID 15743908, Free PMC Article
    2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Sweadner KJ, et al. Genomics, 2000 Aug 15. PMID 10950925
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FXYD domain-containing ion transport regulator 3
    Names
    sodium/potassium-transporting ATPase subunit FXYD3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172317.2 → NP_758528.1  FXYD domain-containing ion transport regulator 3 precursor

      See identical proteins and their annotated locations for NP_758528.1

      Status: REVIEWED

      Source sequence(s)
      BG373727, DY471861
      UniProtKB/Swiss-Prot
      P59645
      UniProtKB/TrEMBL
      A6JA66
      Related
      ENSRNOP00000104598.1, ENSRNOT00000172857.1
      Conserved Domains (1) summary
      cd20328
      Location:20 → 70
      FXYD3-like; FXYD domain-containing ion transport regulator 3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95432918..95440129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266166.1 → XP_063122236.1  FXYD domain-containing ion transport regulator 3 isoform X2

      UniProtKB/Swiss-Prot
      P59645
      UniProtKB/TrEMBL
      A6JA66

    2. XM_063266111.1 → XP_063122181.1  FXYD domain-containing ion transport regulator 3 isoform X1

    3. XM_063266144.1 → XP_063122214.1  FXYD domain-containing ion transport regulator 3 isoform X1

    4. XM_063266203.1 → XP_063122273.1  FXYD domain-containing ion transport regulator 3 isoform X2

      UniProtKB/Swiss-Prot
      P59645
      UniProtKB/TrEMBL
      A6JA66

    5. XM_006228819.5 → XP_006228881.1  FXYD domain-containing ion transport regulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006228881.1

      Conserved Domains (1) summary
      cd20328
      Location:20 → 70
      FXYD3-like; FXYD domain-containing ion transport regulator 3 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59645.1 GenPept UniProtKB/Swiss-Prot:P59645

    Gene LinkOut

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