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    Dixdc1 DIX domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363062, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dixdc1provided by RGD
    Official Full Name
    DIX domain containing 1provided by RGD
    Primary source
    RGD:1309902
    See related
    EnsemblRapid:ENSRNOG00000010260 AllianceGenome:RGD:1309902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccd1
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in cerebellar cortex development; positive regulation of JNK cascade; and positive regulation of axonogenesis. Located in axon terminus and neuronal cell body. Part of protein-containing complex. Orthologous to human DIXDC1 (DIX domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 134.0), Liver (RPKM 56.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dixdc1 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59904218..59977595, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51007835..51081191, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55091232..55164636, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NKAP domain containing 1 Neighboring gene PIH1 domain containing 2 Neighboring gene dihydrolipoamide S-acetyltransferase Neighboring gene uncharacterized LOC120094337 Neighboring gene similar to human chromosome 11 open reading frame 52 Neighboring gene heat shock protein family B (small) member 2 Neighboring gene crystallin, alpha B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell proliferation in forebrain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebellar cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in forebrain ventricular zone progenitor cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain ventricular zone progenitor cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dixin
    Names
    DIX domain-containing protein 1
    coiled-coil protein DIX1
    coiled-coil-DIX1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395147.2NP_001382076.1  dixin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q2VUH7
      UniProtKB/TrEMBL
      A0A8L2QJF6
      Related
      ENSRNOP00000037500.6, ENSRNOT00000039045.7
      Conserved Domains (3) summary
      COG1196
      Location:282567
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd21213
      Location:22128
      CH_DIXDC1; calponin homology (CH) domain found in Dixin and similar proteins
      pfam00778
      Location:602678
      DIX; DIX domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      59904218..59977595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265745.1XP_063121815.1  dixin isoform X3

      Related
      ENSRNOP00000085938.2, ENSRNOT00000100212.2
    2. XM_017595731.3XP_017451220.1  dixin isoform X2

      UniProtKB/TrEMBL
      A0A0G2K662
      Related
      ENSRNOP00000073690.3, ENSRNOT00000083102.3
    3. XM_063265744.1XP_063121814.1  dixin isoform X2

    4. XM_017595733.3XP_017451222.1  dixin isoform X5

      UniProtKB/TrEMBL
      A0A0G2K662
      Conserved Domains (3) summary
      COG1196
      Location:202487
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00778
      Location:522599
      DIX; DIX domain
      cl00030
      Location:148
      CH_SF; calponin homology (CH) domain superfamily
    5. XM_063265746.1XP_063121816.1  dixin isoform X5

    6. XM_017595732.3XP_017451221.1  dixin isoform X4

      UniProtKB/TrEMBL
      A0A8L2QJF6
    7. XM_008766295.4XP_008764517.1  dixin isoform X1

      UniProtKB/TrEMBL
      A0A8L2QJF6
      Conserved Domains (4) summary
      cd00014
      Location:22138
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00778
      Location:614689
      DIX; DIX domain
      pfam02601
      Location:383472
      Exonuc_VII_L; Exonuclease VII, large subunit
      cl19219
      Location:294377
      DUF342; Protein of unknown function (DUF342)
    8. XM_008766296.3XP_008764518.1  dixin isoform X7

      UniProtKB/TrEMBL
      A6J4E9
      Conserved Domains (3) summary
      pfam00778
      Location:391466
      DIX; DIX domain
      pfam02601
      Location:160249
      Exonuc_VII_L; Exonuclease VII, large subunit
      cl19219
      Location:71154
      DUF342; Protein of unknown function (DUF342)
    9. XM_039081729.2XP_038937657.1  dixin isoform X6

      UniProtKB/TrEMBL
      A6J4E9
      Conserved Domains (2) summary
      COG1196
      Location:85370
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00778
      Location:405482
      DIX; DIX domain
    10. XM_039081730.2XP_038937658.1  dixin isoform X8

      UniProtKB/TrEMBL
      A6J4E9
      Conserved Domains (2) summary
      COG1196
      Location:51285
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00778
      Location:320397
      DIX; DIX domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037654.1: Suppressed sequence

      Description
      NM_001037654.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.