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    Nabp1 nucleic acid binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363227, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nabp1provided by RGD
    Official Full Name
    nucleic acid binding protein 1provided by RGD
    Primary source
    RGD:1306658
    See related
    EnsemblRapid:ENSRNOG00000015416 AllianceGenome:RGD:1306658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Obfc2a; RGD1306658
    Summary
    Predicted to enable RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Predicted to be located in chromosome; cytosol; and nucleoplasm. Predicted to be part of SOSS complex. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 225.6), Thymus (RPKM 225.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nabp1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (57570326..57625926)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (50098552..50133982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (55049893..55057784)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL11-like Neighboring gene uncharacterized LOC134480572 Neighboring gene transfer RNA alanine (anticodon AGC) 29 Neighboring gene large ribosomal subunit protein uL14-like Neighboring gene uncharacterized LOC120094683

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC108887

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G2/M transition checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2/M transition checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SOSS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SOSS complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SOSS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SOSS complex subunit B2
    Names
    SOSS-B2
    oligonucleotide/oligosaccharide-binding fold containing 2A
    oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    sensor of single-strand DNA complex subunit B2
    sensor of ssDNA subunit B2
    single-stranded DNA-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014216.2NP_001014238.1  SOSS complex subunit B2

      See identical proteins and their annotated locations for NP_001014238.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5FVP2
      UniProtKB/TrEMBL
      A6INX2
      Related
      ENSRNOP00000021403.3, ENSRNOT00000021403.7
      Conserved Domains (1) summary
      cd04491
      Location:2299
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      57570326..57625926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267373.1XP_063123443.1  SOSS complex subunit B2 isoform X1

      UniProtKB/TrEMBL
      A6INX4
    2. XM_039083850.2XP_038939778.1  SOSS complex subunit B2 isoform X3

      Conserved Domains (1) summary
      cd04491
      Location:473
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
    3. XM_017596514.3XP_017452003.1  SOSS complex subunit B2 isoform X1

      UniProtKB/TrEMBL
      A6INX4
    4. XM_039083849.2XP_038939777.1  SOSS complex subunit B2 isoform X2

      Conserved Domains (1) summary
      cd04491
      Location:2299
      SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
    5. XM_039083851.2XP_038939779.1  SOSS complex subunit B2 isoform X1

      UniProtKB/TrEMBL
      A6INX4