Arhgap24 Rho GTPase activating protein 24 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap24provided by RGD
Official Full Name: Rho GTPase activating protein 24provided by RGD
Primary source: RGD:1306669
See related: EnsemblRapid:ENSRNOG00000056944 AllianceGenome:RGD:1306669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DR-NR#2
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of Rac protein signal transduction; negative regulation of ruffle assembly; and wound healing, spreading of epidermal cells. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in several cellular components, including adherens junction; cell projection; and cytoskeleton. Predicted to be active in focal adhesion. Orthologous to human ARHGAP24 (Rho GTPase activating protein 24). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 258.2), Lung (RPKM 31.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (7105200..7488437, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (6800624..7183877, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (8383211..8600526, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes.
Title: FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of epidermal cells	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 24

Names: Down-regulated in nephrectomized rat kidney #2; rho-type GTPase-activating protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012032.2 → NP_001012032.2 rho GTPase-activating protein 24 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A0U1RRQ9, A0A0X1KG81

Related

ENSRNOP00000075613.2, ENSRNOT00000089800.4

Conserved Domains (2) summary

COG1196
Location:558 → 644

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:39 → 237

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
NM_001393820.1 → NP_001380749.1 rho GTPase-activating protein 24 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q5U2Z7, Q6I7R2

UniProtKB/TrEMBL

A0A0U1RRQ9, A6K5V9

Related

ENSRNOP00000072212.2, ENSRNOT00000080758.4

Conserved Domains (3) summary

COG1196
Location:649 → 735

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:130 → 328

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cd13379
Location:17 → 130

PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

7105200..7488437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091823.2 → XP_038947751.1 rho GTPase-activating protein 24 isoform X1

Related

ENSRNOP00000099081.1, ENSRNOT00000141948.1

Conserved Domains (3) summary

COG1196
Location:686 → 772

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04390
Location:167 → 365

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

cd13379
Location:54 → 167

PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain
XM_063273047.1 → XP_063129117.1 rho GTPase-activating protein 24 isoform X3

UniProtKB/TrEMBL

A0A0G2K2E5, A0A0U1RRQ9, A6K5W0
XM_006250652.5 → XP_006250714.1 rho GTPase-activating protein 24 isoform X3

See identical proteins and their annotated locations for XP_006250714.1

UniProtKB/TrEMBL

A0A0G2K2E5, A0A0U1RRQ9, A6K5W0

Conserved Domains (4) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam00169
Location:4 → 29

PH; PH domain

pfam15035
Location:567 → 644

Rootletin; Ciliary rootlet component, centrosome cohesion

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_017599166.3 → XP_017454655.1 rho GTPase-activating protein 24 isoform X3

UniProtKB/TrEMBL

A0A0G2K2E5, A0A0U1RRQ9, A6K5W0

Conserved Domains (4) summary

cd04390
Location:36 → 234

RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...

pfam00169
Location:4 → 29

PH; PH domain

pfam15035
Location:567 → 644

Rootletin; Ciliary rootlet component, centrosome cohesion

cl17171
Location:1 → 36

PH-like; Pleckstrin homology-like domain
XM_063273046.1 → XP_063129116.1 rho GTPase-activating protein 24 isoform X2

UniProtKB/TrEMBL

A0A0U1RRQ9