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    Ddhd1 DDHD domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305816, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ddhd1provided by RGD
    Official Full Name
    DDHD domain containing 1provided by RGD
    Primary source
    RGD:1308576
    See related
    EnsemblRapid:ENSRNOG00000009481 AllianceGenome:RGD:1308576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase activity. Predicted to act upstream of or within positive regulation of mitochondrial fission and sperm mitochondrion organization. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28. Orthologous to human DDHD1 (DDHD domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 135.8), Brain (RPKM 77.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ddhd1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (21304053..21370608, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18824389..18891036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19963639..20032263, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 like 6 Neighboring gene U6 spliceosomal RNA Neighboring gene FERM domain containing kindlin 2 Neighboring gene ribosomal protein S29, pseudogene 19 Neighboring gene uncharacterized LOC108352894 Neighboring gene uncharacterized LOC108352895 Neighboring gene uncharacterized LOC134481954

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC125147

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sperm mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phospholipase DDHD1
    NP_001028238.1
    XP_006251831.1
    XP_006251832.1
    XP_006251834.1
    XP_006251835.1
    XP_006251836.1
    XP_038949183.1
    XP_038949185.1
    XP_063130275.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033066.3NP_001028238.1  phospholipase DDHD1 isoform 7

      See identical proteins and their annotated locations for NP_001028238.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      Q3ZAU5
      Conserved Domains (1) summary
      pfam02862
      Location:597840
      DDHD; DDHD domain
    2. NM_001431405.1NP_001418334.1  phospholipase DDHD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZK24
    3. NM_001431406.1NP_001418335.1  phospholipase DDHD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    4. NM_001431407.1NP_001418336.1  phospholipase DDHD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AX45
    5. NM_001431408.1NP_001418337.1  phospholipase DDHD1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZSB2
    6. NM_001431409.1NP_001418338.1  phospholipase DDHD1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    7. NM_001431410.1NP_001418339.1  phospholipase DDHD1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ADX7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      21304053..21370608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251773.5XP_006251835.1  phospholipase DDHD1 isoform X6

      Related
      ENSRNOP00000035399.5, ENSRNOT00000032704.7
      Conserved Domains (1) summary
      pfam02862
      Location:597868
      DDHD; DDHD domain
    2. XM_063274205.1XP_063130275.1  phospholipase DDHD1 isoform X5

    3. XM_006251770.5XP_006251832.1  phospholipase DDHD1 isoform X2

      Related
      ENSRNOP00000081184.2, ENSRNOT00000114252.2
      Conserved Domains (1) summary
      pfam02862
      Location:631902
      DDHD; DDHD domain
    4. XM_006251774.5XP_006251836.1  phospholipase DDHD1 isoform X7

      Conserved Domains (1) summary
      pfam02862
      Location:604847
      DDHD; DDHD domain
    5. XM_006251772.5XP_006251834.1  phospholipase DDHD1 isoform X4

      Related
      ENSRNOP00000092577.2, ENSRNOT00000111596.2
      Conserved Domains (1) summary
      pfam02862
      Location:604875
      DDHD; DDHD domain
    6. XM_039093255.2XP_038949183.1  phospholipase DDHD1 isoform X3

      Related
      ENSRNOP00000093499.1, ENSRNOT00000102887.2
      Conserved Domains (1) summary
      pfam02862
      Location:638881
      DDHD; DDHD domain
    7. XM_006251769.5XP_006251831.1  phospholipase DDHD1 isoform X1

      Conserved Domains (1) summary
      pfam02862
      Location:638909
      DDHD; DDHD domain
    8. XM_039093257.2XP_038949185.1  phospholipase DDHD1 isoform X8