Psmc4 proteasome 26S subunit, ATPase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmc4provided by RGD
Official Full Name: proteasome 26S subunit, ATPase 4provided by RGD
Primary source: RGD:621102
See related: EnsemblRapid:ENSRNOG00000018994 AllianceGenome:RGD:621102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tbp7
Summary: Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 431.0), Heart (RPKM 407.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (92476690..92485268, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (83349127..83357497, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (84978220..84986536, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Psmc4 (e-PCR), detects polymorphism
- UniSTS:498274

STS-T26522 (e-PCR)
- UniSTS:69583

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	TAS Traceable Author Statement more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of cytosolic proteasome complex	IDA Inferred from Direct Assay more info	PubMed
located_in inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome accessory complex	ISO Inferred from Sequence Orthology more info
part_of proteasome accessory complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome regulatory subunit 6B

Names: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; S6 ATPase; TAT-binding protein 7; TBP-7; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057122.2 → NP_476463.1 26S proteasome regulatory subunit 6B

See identical proteins and their annotated locations for NP_476463.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63570

UniProtKB/TrEMBL

A6J9G3

Related

ENSRNOP00000025819.3, ENSRNOT00000025819.7

Conserved Domains (1) summary

PTZ00454
Location:34 → 418

PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional