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    Polr2m RNA polymerase II subunit M [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192147, updated on 9-Dec-2024

    Summary

    Official Symbol
    Polr2mprovided by RGD
    Official Full Name
    RNA polymerase II subunit Mprovided by RGD
    Primary source
    RGD:619847
    See related
    EnsemblRapid:ENSRNOG00000057676 AllianceGenome:RGD:619847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glurr; Grinl1a
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in maintenance of ER location. Predicted to be located in neuronal cell body and nuclear envelope. Predicted to be part of RNA polymerase II, core complex and transcription preinitiation complex. Predicted to be active in I band. Orthologous to human POLR2M (RNA polymerase II subunit M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 298.8), Heart (RPKM 292.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Polr2m in Genome Data Viewer
    Location:
    8q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81012770..81020201, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72131992..72139423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77985190..77992621, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family, member A2 Neighboring gene uncharacterized LOC134480072 Neighboring gene uncharacterized LOC120094203 Neighboring gene myocardial zonula adherens protein Neighboring gene dynein light chain LC8-type 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in maintenance of ER location IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in maintenance of ER location ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in I band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription preinitiation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase II subunit GRINL1A
    Names
    DNA-directed RNA polymerase II subunit M
    glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
    glutamate receptor-like protein 1A
    polymerase (RNA) II (DNA directed) polypeptide M
    polymerase (RNA) II subunit M
    protein GRINL1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183402.2NP_899652.1  DNA-directed RNA polymerase II subunit GRINL1A

      See identical proteins and their annotated locations for NP_899652.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q91XQ4
      UniProtKB/TrEMBL
      A6KER1
      Related
      ENSRNOP00000072186.1, ENSRNOT00000085843.3
      Conserved Domains (1) summary
      pfam15328
      Location:37237
      GCOM2; Putative GRINL1B complex locus protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      81012770..81020201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)