QDR2 cation transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: QDR2
Official Full Name: cation transporter
Primary source: SGD:S000001383
Locus tag: YIL121W
See related: AllianceGenome:SGD:S000001383; FungiDB:YIL121W; VEuPathDB:YIL121W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables monoatomic cation transmembrane transporter activity; threonine efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in amino acid export across plasma membrane; copper ion export; and potassium ion import across plasma membrane. Located in cell periphery. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Free divalent copper is the main physiological substrate of Qdr2.
Title: Role of the yeast multidrug transporter Qdr2 in cation homeostasis and the oxidative stress response.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables threonine efflux transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in potassium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in threonine transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_012145.1

Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper

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The following sections contain reference sequences that belong to a specific genome build. Explain