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    Y64G10A.7 Multiple epidermal growth factor-like domains protein 6 [ Caenorhabditis elegans ]

    Gene ID: 178377, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y64G10A.7
    Official Full Name
    Multiple epidermal growth factor-like domains protein 6
    Primary source
    WormBase:WBGene00013416
    Locus tag
    CELE_Y64G10A.7
    See related
    AllianceGenome:WB:WBGene00013416
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y64G10A.7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    24
    Sequence:
    Chromosome: IV; NC_003282.8 (14291901..14319591)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF38 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Multiple epidermal growth factor-like domains protein 6
    NP_001255802.1
    • Partially confirmed by transcript evidence
    NP_001255803.1
    • Confirmed by transcript evidence
    NP_001293936.1
    • Confirmed by transcript evidence
    NP_001294080.1
    • Confirmed by transcript evidence
    NP_001294081.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14291901..14319591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268874.3 → NP_001255803.1  Multiple epidermal growth factor-like domains protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECL0
      Conserved Domains (3) summary
      pfam07546
      Location:34 → 104
      EMI; EMI domain
      pfam14670
      Location:449 → 484
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:319 → 358
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001307152.3 → NP_001294081.1  Multiple epidermal growth factor-like domains protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTK8
      Conserved Domains (3) summary
      pfam07546
      Location:35 → 105
      EMI; EMI domain
      pfam14670
      Location:449 → 484
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:319 → 358
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. NM_001307151.3 → NP_001294080.1  Multiple epidermal growth factor-like domains protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NVB8
      Conserved Domains (3) summary
      pfam07546
      Location:35 → 105
      EMI; EMI domain
      pfam14670
      Location:449 → 484
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:319 → 358
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. NM_001268873.3 → NP_001255802.1  Multiple epidermal growth factor-like domains protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFX3
      Conserved Domains (3) summary
      pfam07546
      Location:34 → 104
      EMI; EMI domain
      pfam14670
      Location:509 → 544
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:319 → 358
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. NM_001307007.3 → NP_001293936.1  Multiple epidermal growth factor-like domains protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293936.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKU0
      Conserved Domains (3) summary
      pfam07546
      Location:35 → 105
      EMI; EMI domain
      pfam14670
      Location:449 → 484
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:319 → 358
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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