gtf-2H5 General transcription and DNA repair factor IIH subunit TFB5 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: gtf-2H5
Official Full Name: General transcription and DNA repair factor IIH subunit TFB5
Primary source: WormBase:WBGene00021904
Locus tag: CELE_Y55B1AL.2
See related: AllianceGenome:WB:WBGene00021904
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Contributes to damaged DNA binding activity. Involved in nucleotide-excision repair and transcription by RNA polymerase II. Predicted to be located in chromosome and nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed widely. Used to study trichothiodystrophy. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See gtf-2H5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003281.10 (576960..577567, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair.
Title: C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y55B1A_122.b (e-PCR)
- UniSTS:324425

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to damaged DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair, preincision complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH core complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	TAS Traceable Author Statement more info	PubMed
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: General transcription and DNA repair factor IIH subunit TFB5

NP_497212.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

576960..577567 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064811.8 → NP_497212.1 General transcription and DNA repair factor IIH subunit TFB5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497212.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N390

Conserved Domains (1) summary

pfam06331
Location:1 → 67

Tfb5; Transcription factor TFIIH complex subunit Tfb5