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    C09D4.1 putative MFS-type transporter C09D4.1 [ Caenorhabditis elegans ]

    Gene ID: 172203, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C09D4.1
    Official Full Name
    putative MFS-type transporter C09D4.1
    Primary source
    WormBase:WBGene00015632
    Locus tag
    CELE_C09D4.1
    See related
    AllianceGenome:WB:WBGene00015632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in heme export. Predicted to be active in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR1 (FLVCR choline and heme transporter 1) and FLVCR2 (FLVCR choline and putative heme transporter 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C09D4.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (5497679..5505460)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DUF4773 domain-containing protein Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL24m Neighboring gene Zinc transporter ZIP11 Neighboring gene RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative MFS-type transporter C09D4.1
    NP_001020991.1
    • Confirmed by transcript evidence
    NP_001020992.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5497679..5505460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025820.5 → NP_001020991.1  putative MFS-type transporter C09D4.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01735, Q5W618
      Conserved Domains (2) summary
      cd06174
      Location:154 → 553
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:154 → 517
      MFS_1; Major Facilitator Superfamily

    2. NM_001025821.6 → NP_001020992.1  putative MFS-type transporter C09D4.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01735
      Conserved Domains (2) summary
      cd06174
      Location:43 → 442
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:55 → 406
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01735.2

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