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    R09H10.3 putative 5-hydroxyisourate hydrolase R09H10.3 [ Caenorhabditis elegans ]

    Gene ID: 187757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R09H10.3
    Official Full Name
    putative 5-hydroxyisourate hydrolase R09H10.3
    Primary source
    WormBase:WBGene00011181
    Locus tag
    CELE_R09H10.3
    See related
    AllianceGenome:WB:WBGene00011181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R09H10.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (10607030..10608428)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene ncRNA Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyisourate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative 5-hydroxyisourate hydrolase R09H10.3
    NP_001040980.1
    • Confirmed by transcript evidence
    NP_001040981.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10607030..10608428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047515.6 → NP_001040980.1  putative 5-hydroxyisourate hydrolase R09H10.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1NZ16, Q21882
      Conserved Domains (1) summary
      TIGR02962
      Location:25 → 135
      hdxy_isourate; hydroxyisourate hydrolase

    2. NM_001047516.5 → NP_001040981.1  putative 5-hydroxyisourate hydrolase R09H10.3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21882
      Conserved Domains (1) summary
      TIGR02962
      Location:11 → 121
      hdxy_isourate; hydroxyisourate hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21882.2

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