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    ttc-4 Cns1/TTC4 wheel domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173946, updated on 9-Dec-2024

    Summary

    Official Symbol
    ttc-4
    Official Full Name
    Cns1/TTC4 wheel domain-containing protein
    Primary source
    WormBase:WBGene00015916
    Locus tag
    CELE_C17G10.2
    See related
    AllianceGenome:WB:WBGene00015916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Predicted to be involved in protein folding. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and vulval muscle. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ttc-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (5594714..5596456)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene LYSozyme Neighboring gene THAP-type domain-containing protein Neighboring gene Tyrosine-protein phosphatase cdc-14 Neighboring gene uS12 prolyl 3-hydroxylase Neighboring gene DUF4440 domain-containing protein Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Cns1/TTC4 wheel domain-containing protein
    NP_495087.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5594714..5596456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062686.6NP_495087.1  Cns1/TTC4 wheel domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09974
      Conserved Domains (2) summary
      sd00006
      Location:95123
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:94164
      TPR_11; TPR repeat