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    F21G4.1 Solute carrier organic anion transporter family member [ Caenorhabditis elegans ]

    Gene ID: 181203, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F21G4.1
    Official Full Name
    Solute carrier organic anion transporter family member
    Primary source
    WormBase:WBGene00009023
    Locus tag
    CELE_F21G4.1
    See related
    AllianceGenome:WB:WBGene00009023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO2A1 (solute carrier organic anion transporter family member 2A1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F21G4.1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (9889633..9892328, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Ras-related protein Rab Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Multidrug resistance-associated protein 1 Neighboring gene Methyltransf_21 domain-containing protein Neighboring gene PHD-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Solute carrier organic anion transporter family member
    NP_509659.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9889633..9892328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077258.7 → NP_509659.3  Solute carrier organic anion transporter family member [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509659.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93550
      Conserved Domains (3) summary
      cd06174
      Location:20 → 402
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:433 → 481
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:18 → 586
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    Nucleotide Protein
    Heading Accession and Version

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